| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 540 | 86 | 56 | 0.318 | 0.359 | 1.89 | 2B |
| Kevin Youkilis | 471 | 72 | 81 | 0.316 | 0.384 | 4.71 | 1B-3B |
| Jacoby Ellsbury | 440 | 66 | 34 | 0.272 | 0.334 | -0.11 | CF-LF-RF |
| J.D. Drew | 437 | 78 | 63 | 0.288 | 0.416 | 4.27 | RF |
| Mike Lowell | 427 | 52 | 67 | 0.270 | 0.335 | 2.20 | 3B |
| Manny Ramirez | 425 | 68 | 70 | 0.299 | 0.398 | 4.24 | LF |
| Jason Varitek | 361 | 25 | 32 | 0.216 | 0.305 | -2.72 | CR |
| David Ortiz | 320 | 47 | 59 | 0.260 | 0.359 | 3.42 | DH |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.26 | SS |
| Coco Crisp | 292 | 33 | 27 | 0.247 | 0.295 | -0.74 | CF |
| Sean Casey | 165 | 13 | 11 | 0.353 | 0.412 | -1.46 | 1B-DH |
| Jed Lowrie | 138 | 12 | 26 | 0.286 | 0.341 | 0.66 | SS-3B |
| Kevin Cash | 119 | 8 | 11 | 0.222 | 0.286 | -0.87 | CR |
| Alex Cora | 87 | 5 | 5 | 0.280 | 0.368 | -1.05 | SS |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jason Bay | 52 | 13 | 9 | 0.319 | 0.385 | 1.06 | LF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jeff Bailey | 8 | 1 | 0 | 0.000 | 0.375 | -0.09 | 1B |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 153.3 | 3.23 | 24 | 0 | X | 3.80 |
| Josh Beckett | 147.0 | 3.92 | 22 | 0 | X | 1.27 |
| Tim Wakefield | 147.0 | 3.67 | 23 | 0 | X | 2.11 |
| Daisuke Matsuzaka | 114.7 | 2.90 | 20 | 0 | X | 3.71 |
| Clay Buchholz | 72.7 | 6.32 | 14 | 0 | X | -3.44 |
| Justin Masterson | 66.0 | 3.41 | 9 | 8 | X | 1.36 |
| Jonathan Papelbon | 51.3 | 1.93 | 0 | 50 | X | 2.83 |
| Manny Delcarmen | 50.0 | 4.32 | 0 | 53 | X | -0.04 |
| Hideki Okajima | 46.7 | 2.51 | 0 | 47 | X | 1.94 |
| Javier Lopez | 43.3 | 2.70 | 0 | 51 | X | 1.61 |
| David Aardsma | 41.0 | 3.73 | 0 | 40 | X | 0.53 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.15 |
| Mike Timlin | 32.7 | 5.23 | 0 | 34 | X | -0.72 |
| Craig Hansen | 30.7 | 5.58 | 0 | 32 | X | -0.92 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.62 |
| Chris Smith | 8.3 | 2.16 | 0 | 5 | X | 0.41 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| Charlie Zink | 4.3 | 16.62 | 1 | 0 | X | -1.25 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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