| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 482 | 72 | 48 | 0.314 | 0.355 | 0.99 | 2B |
| Kevin Youkilis | 418 | 65 | 68 | 0.311 | 0.380 | 3.90 | 1B-3B |
| Manny Ramirez | 417 | 68 | 70 | 0.304 | 0.400 | 4.45 | LF |
| Jacoby Ellsbury | 406 | 60 | 28 | 0.264 | 0.328 | -0.54 | CF-LF-RF |
| J.D. Drew | 382 | 68 | 58 | 0.288 | 0.406 | 4.03 | RF |
| Mike Lowell | 374 | 43 | 63 | 0.283 | 0.348 | 2.12 | 3B |
| Jason Varitek | 321 | 21 | 31 | 0.218 | 0.302 | -2.27 | CR |
| Julio Lugo | 307 | 27 | 22 | 0.268 | 0.352 | -2.25 | SS |
| David Ortiz | 264 | 41 | 47 | 0.265 | 0.360 | 2.88 | DH |
| Coco Crisp | 263 | 31 | 22 | 0.248 | 0.300 | -0.77 | CF |
| Sean Casey | 148 | 12 | 11 | 0.356 | 0.412 | -1.15 | 1B-DH |
| Kevin Cash | 108 | 7 | 11 | 0.235 | 0.296 | -0.71 | CR |
| Brandon Moss | 86 | 7 | 11 | 0.295 | 0.337 | -0.18 | LF-RF |
| Jed Lowrie | 86 | 6 | 11 | 0.284 | 0.337 | -0.29 | SS-3B |
| Alex Cora | 76 | 4 | 5 | 0.292 | 0.382 | -0.89 | SS |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jeff Bailey | 8 | 1 | 0 | 0.000 | 0.375 | -0.09 | 1B |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 139.3 | 3.17 | 22 | 0 | X | 3.59 |
| Tim Wakefield | 134.7 | 3.94 | 21 | 0 | X | 1.02 |
| Josh Beckett | 127.0 | 3.83 | 19 | 0 | X | 1.31 |
| Daisuke Matsuzaka | 100.7 | 3.04 | 18 | 0 | X | 2.89 |
| Justin Masterson | 58.7 | 3.68 | 9 | 3 | X | 0.80 |
| Clay Buchholz | 57.3 | 5.81 | 11 | 0 | X | -2.06 |
| Jonathan Papelbon | 44.3 | 2.23 | 0 | 44 | X | 2.11 |
| Manny Delcarmen | 43.3 | 4.36 | 0 | 47 | X | -0.09 |
| Hideki Okajima | 41.0 | 2.63 | 0 | 42 | X | 1.56 |
| Javier Lopez | 40.7 | 2.66 | 0 | 47 | X | 1.53 |
| David Aardsma | 39.3 | 2.75 | 0 | 38 | X | 1.40 |
| Bartolo Colon | 33.0 | 4.09 | 6 | 0 | X | 0.14 |
| Craig Hansen | 30.0 | 5.70 | 0 | 31 | X | -1.00 |
| Mike Timlin | 29.3 | 5.52 | 0 | 31 | X | -0.86 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.63 |
| Chris Smith | 6.3 | 2.84 | 0 | 3 | X | 0.21 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.87 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.67 |
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