| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 317 | 41 | 31 | 0.261 | 0.306 | -0.03 | 2B |
| Kevin Youkilis | 282 | 44 | 44 | 0.305 | 0.376 | 2.49 | 1B-3B |
| Manny Ramirez | 281 | 46 | 50 | 0.301 | 0.388 | 3.35 | LF |
| Jacoby Ellsbury | 254 | 47 | 23 | 0.289 | 0.370 | 1.27 | CF-LF-RF |
| David Ortiz | 246 | 37 | 43 | 0.252 | 0.354 | 2.51 | DH |
| J.D. Drew | 236 | 50 | 38 | 0.321 | 0.428 | 3.59 | RF |
| Julio Lugo | 229 | 18 | 14 | 0.273 | 0.354 | -2.12 | SS |
| Mike Lowell | 218 | 28 | 36 | 0.279 | 0.335 | 1.50 | 3B |
| Jason Varitek | 206 | 17 | 24 | 0.254 | 0.330 | -0.63 | CR |
| Coco Crisp | 184 | 18 | 19 | 0.256 | 0.293 | -0.52 | CF |
| Sean Casey | 98 | 6 | 8 | 0.367 | 0.418 | -0.88 | 1B-DH |
| Kevin Cash | 81 | 4 | 6 | 0.236 | 0.309 | -0.89 | CR |
| Alex Cora | 50 | 3 | 2 | 0.302 | 0.400 | -0.67 | SS |
| Jed Lowrie | 48 | 6 | 7 | 0.310 | 0.333 | 0.22 | SS-3B |
| Brandon Moss | 37 | 4 | 3 | 0.242 | 0.324 | -0.15 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Jeff Bailey | 6 | 1 | 0 | 0.000 | 0.500 | -0.04 | 1B |
| Chris Carter | 3 | 1 | 0 | 0.667 | 0.667 | 0.03 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 89.3 | 3.43 | 15 | 0 | X | 1.65 |
| Tim Wakefield | 88.0 | 4.19 | 14 | 0 | X | 0.05 |
| Josh Beckett | 86.0 | 3.87 | 13 | 0 | X | 0.69 |
| Daisuke Matsuzaka | 64.0 | 2.53 | 11 | 0 | X | 2.52 |
| Clay Buchholz | 42.3 | 5.53 | 8 | 0 | X | -1.29 |
| David Aardsma | 31.3 | 2.87 | 0 | 28 | X | 0.98 |
| Justin Masterson | 31.0 | 2.90 | 5 | 0 | X | 0.95 |
| Jonathan Papelbon | 30.3 | 2.08 | 0 | 30 | X | 1.52 |
| Bartolo Colon | 29.0 | 3.41 | 5 | 0 | X | 0.54 |
| Manny Delcarmen | 28.3 | 3.81 | 0 | 31 | X | 0.27 |
| Hideki Okajima | 28.3 | 3.18 | 0 | 28 | X | 0.69 |
| Javier Lopez | 24.7 | 2.55 | 0 | 32 | X | 0.96 |
| Mike Timlin | 21.0 | 5.57 | 0 | 23 | X | -0.66 |
| Craig Hansen | 18.7 | 4.82 | 0 | 17 | X | -0.26 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.64 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
_