| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 232 | 29 | 26 | 0.299 | 0.332 | 0.28 | 2B |
| David Ortiz | 216 | 31 | 38 | 0.245 | 0.352 | 2.13 | DH |
| Kevin Youkilis | 210 | 32 | 35 | 0.317 | 0.381 | 2.06 | 1B-3B |
| Manny Ramirez | 206 | 30 | 28 | 0.280 | 0.364 | 1.21 | LF |
| Jacoby Ellsbury | 175 | 37 | 19 | 0.297 | 0.394 | 1.74 | CF-LF-RF |
| Julio Lugo | 162 | 14 | 13 | 0.292 | 0.352 | -1.00 | SS |
| J.D. Drew | 159 | 31 | 22 | 0.289 | 0.390 | 1.80 | RF |
| Jason Varitek | 145 | 14 | 18 | 0.295 | 0.372 | -0.07 | CR |
| Mike Lowell | 134 | 18 | 19 | 0.285 | 0.336 | 0.71 | 3B |
| Coco Crisp | 113 | 13 | 10 | 0.295 | 0.319 | -0.26 | CF |
| Sean Casey | 69 | 6 | 8 | 0.355 | 0.420 | -0.16 | 1B-DH |
| Kevin Cash | 57 | 4 | 5 | 0.314 | 0.368 | -0.40 | CR |
| Jed Lowrie | 48 | 6 | 7 | 0.310 | 0.333 | 0.23 | SS-3B |
| Alex Cora | 25 | 0 | 1 | 0.409 | 0.480 | -0.49 | SS |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Jonathan Van Every | 3 | 0 | 0 | 0.333 | 0.333 | -0.07 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 66.0 | 3.41 | 11 | 0 | X | 1.25 |
| Daisuke Matsuzaka | 60.0 | 2.40 | 10 | 0 | X | 2.55 |
| Tim Wakefield | 59.0 | 5.19 | 10 | 0 | X | -1.33 |
| Josh Beckett | 54.0 | 4.67 | 8 | 0 | X | -0.57 |
| Clay Buchholz | 42.3 | 5.53 | 8 | 0 | X | -1.29 |
| David Aardsma | 23.0 | 3.13 | 0 | 21 | X | 0.58 |
| Jonathan Papelbon | 23.0 | 2.35 | 0 | 22 | X | 1.00 |
| Hideki Okajima | 20.0 | 0.90 | 0 | 19 | X | 1.55 |
| Manny Delcarmen | 18.3 | 5.40 | 0 | 22 | X | -0.51 |
| Javier Lopez | 18.3 | 2.95 | 0 | 24 | X | 0.54 |
| Mike Timlin | 14.0 | 7.07 | 0 | 16 | X | -0.93 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.64 |
| Justin Masterson | 12.3 | 1.46 | 2 | 0 | X | 0.79 |
| Craig Hansen | 8.3 | 7.56 | 0 | 8 | X | -0.65 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Bartolo Colon | 5.0 | 3.60 | 1 | 0 | X | 0.07 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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