| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 192 | 21 | 20 | 0.305 | 0.339 | -0.20 | 2B |
| David Ortiz | 178 | 25 | 29 | 0.240 | 0.343 | 1.50 | DH |
| Kevin Youkilis | 174 | 27 | 30 | 0.313 | 0.391 | 1.91 | 1B-3B |
| Manny Ramirez | 172 | 27 | 27 | 0.309 | 0.390 | 1.64 | LF |
| Jacoby Ellsbury | 139 | 28 | 13 | 0.265 | 0.374 | 1.05 | CF-LF-RF |
| Julio Lugo | 136 | 10 | 9 | 0.285 | 0.346 | -1.19 | SS |
| J.D. Drew | 136 | 25 | 17 | 0.296 | 0.397 | 1.22 | RF |
| Jason Varitek | 122 | 9 | 14 | 0.255 | 0.328 | -0.44 | CR |
| Mike Lowell | 102 | 11 | 10 | 0.263 | 0.304 | -0.19 | 3B |
| Coco Crisp | 96 | 12 | 9 | 0.315 | 0.333 | -0.05 | CF |
| Sean Casey | 65 | 6 | 8 | 0.345 | 0.415 | -0.05 | 1B-DH |
| Jed Lowrie | 48 | 6 | 7 | 0.310 | 0.333 | 0.24 | SS-3B |
| Kevin Cash | 46 | 3 | 5 | 0.375 | 0.435 | -0.24 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Alex Cora | 17 | 0 | 1 | 0.600 | 0.647 | -0.29 | SS |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 51.0 | 4.06 | 9 | 0 | X | 0.20 |
| Tim Wakefield | 48.7 | 4.25 | 8 | 0 | X | -0.03 |
| Daisuke Matsuzaka | 47.7 | 2.45 | 8 | 0 | X | 1.97 |
| Josh Beckett | 47.0 | 4.21 | 7 | 0 | X | 0.02 |
| Clay Buchholz | 42.3 | 5.53 | 8 | 0 | X | -1.28 |
| David Aardsma | 20.3 | 2.21 | 0 | 18 | X | 0.96 |
| Jonathan Papelbon | 18.7 | 2.41 | 0 | 18 | X | 0.79 |
| Hideki Okajima | 18.0 | 0.50 | 0 | 17 | X | 1.57 |
| Javier Lopez | 15.0 | 3.00 | 0 | 18 | X | 0.43 |
| Manny Delcarmen | 14.7 | 6.14 | 0 | 18 | X | -0.65 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.64 |
| Mike Timlin | 10.0 | 9.00 | 0 | 13 | X | -1.11 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Craig Hansen | 5.3 | 5.06 | 0 | 4 | X | -0.10 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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