| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 182 | 21 | 20 | 0.304 | 0.341 | 0.03 | 2B |
| Kevin Youkilis | 170 | 27 | 30 | 0.322 | 0.400 | 1.99 | 1B-3B |
| David Ortiz | 168 | 23 | 28 | 0.241 | 0.345 | 1.41 | DH |
| Manny Ramirez | 162 | 25 | 24 | 0.299 | 0.377 | 1.34 | LF |
| Jacoby Ellsbury | 137 | 27 | 13 | 0.268 | 0.372 | 0.98 | CF-LF-RF |
| Julio Lugo | 136 | 10 | 9 | 0.285 | 0.346 | -1.20 | SS |
| J.D. Drew | 130 | 25 | 17 | 0.284 | 0.392 | 1.36 | RF |
| Jason Varitek | 114 | 9 | 14 | 0.262 | 0.333 | -0.26 | CR |
| Mike Lowell | 93 | 11 | 9 | 0.279 | 0.323 | -0.08 | 3B |
| Coco Crisp | 88 | 10 | 9 | 0.317 | 0.330 | -0.07 | CF |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.08 | 1B-DH |
| Jed Lowrie | 48 | 6 | 7 | 0.310 | 0.333 | 0.24 | SS-3B |
| Kevin Cash | 46 | 3 | 5 | 0.375 | 0.435 | -0.24 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Alex Cora | 9 | 0 | 0 | 0.857 | 0.889 | -0.21 | SS |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 51.0 | 4.06 | 9 | 0 | X | 0.19 |
| Tim Wakefield | 48.7 | 4.25 | 8 | 0 | X | -0.04 |
| Daisuke Matsuzaka | 47.7 | 2.45 | 8 | 0 | X | 1.96 |
| Josh Beckett | 41.3 | 3.70 | 6 | 0 | X | 0.50 |
| Clay Buchholz | 38.0 | 4.50 | 7 | 0 | X | -0.25 |
| David Aardsma | 19.3 | 2.33 | 0 | 17 | X | 0.85 |
| Jonathan Papelbon | 18.7 | 2.41 | 0 | 18 | X | 0.79 |
| Hideki Okajima | 18.0 | 0.50 | 0 | 17 | X | 1.56 |
| Javier Lopez | 13.3 | 3.37 | 0 | 17 | X | 0.26 |
| Manny Delcarmen | 13.3 | 6.75 | 0 | 17 | X | -0.79 |
| Julian Tavarez | 12.7 | 6.39 | 0 | 9 | X | -0.64 |
| Mike Timlin | 9.0 | 10.00 | 0 | 12 | X | -1.21 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Craig Hansen | 4.3 | 6.23 | 0 | 3 | X | -0.20 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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