| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 177 | 20 | 20 | 0.305 | 0.339 | 0.04 | 2B |
| Kevin Youkilis | 165 | 26 | 29 | 0.319 | 0.400 | 1.90 | 1B-3B |
| David Ortiz | 163 | 23 | 28 | 0.234 | 0.337 | 1.53 | DH |
| Manny Ramirez | 161 | 25 | 24 | 0.301 | 0.379 | 1.37 | LF |
| Julio Lugo | 136 | 10 | 9 | 0.285 | 0.346 | -1.20 | SS |
| Jacoby Ellsbury | 132 | 26 | 13 | 0.278 | 0.379 | 1.00 | CF-LF-RF |
| J.D. Drew | 125 | 24 | 16 | 0.279 | 0.392 | 1.27 | RF |
| Jason Varitek | 114 | 9 | 14 | 0.262 | 0.333 | -0.26 | CR |
| Mike Lowell | 88 | 10 | 8 | 0.280 | 0.330 | -0.18 | 3B |
| Coco Crisp | 83 | 8 | 7 | 0.312 | 0.325 | -0.37 | CF |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.08 | 1B-DH |
| Jed Lowrie | 48 | 6 | 7 | 0.310 | 0.333 | 0.24 | SS-3B |
| Kevin Cash | 42 | 2 | 4 | 0.361 | 0.429 | -0.36 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 51.0 | 4.06 | 9 | 0 | X | 0.15 |
| Daisuke Matsuzaka | 47.7 | 2.45 | 8 | 0 | X | 1.92 |
| Tim Wakefield | 46.0 | 3.33 | 7 | 0 | X | 0.92 |
| Josh Beckett | 41.3 | 3.70 | 6 | 0 | X | 0.47 |
| Clay Buchholz | 38.0 | 4.50 | 7 | 0 | X | -0.28 |
| Jonathan Papelbon | 18.7 | 2.41 | 0 | 18 | X | 0.77 |
| Hideki Okajima | 18.0 | 0.50 | 0 | 17 | X | 1.55 |
| David Aardsma | 17.3 | 2.60 | 0 | 16 | X | 0.64 |
| Manny Delcarmen | 13.3 | 6.75 | 0 | 17 | X | -0.80 |
| Javier Lopez | 13.0 | 3.46 | 0 | 16 | X | 0.22 |
| Julian Tavarez | 11.3 | 7.15 | 0 | 8 | X | -0.78 |
| Mike Timlin | 7.3 | 11.05 | 0 | 11 | X | -1.17 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Craig Hansen | 4.3 | 6.23 | 0 | 3 | X | -0.21 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.63 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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