| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 167 | 19 | 19 | 0.299 | 0.335 | 0.03 | 2B |
| Kevin Youkilis | 155 | 24 | 27 | 0.313 | 0.400 | 1.68 | 1B-3B |
| David Ortiz | 153 | 22 | 28 | 0.239 | 0.333 | 1.62 | DH |
| Manny Ramirez | 151 | 24 | 24 | 0.316 | 0.397 | 1.46 | LF |
| Julio Lugo | 132 | 10 | 8 | 0.286 | 0.348 | -1.24 | SS |
| Jacoby Ellsbury | 122 | 26 | 13 | 0.290 | 0.393 | 1.20 | CF-LF-RF |
| J.D. Drew | 120 | 23 | 16 | 0.277 | 0.383 | 1.25 | RF |
| Jason Varitek | 105 | 9 | 13 | 0.253 | 0.324 | -0.18 | CR |
| Coco Crisp | 79 | 7 | 6 | 0.315 | 0.329 | -0.51 | CF |
| Mike Lowell | 78 | 8 | 5 | 0.260 | 0.308 | -0.48 | 3B |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.07 | 1B-DH |
| Jed Lowrie | 44 | 4 | 6 | 0.263 | 0.295 | 0.01 | SS-3B |
| Kevin Cash | 42 | 2 | 4 | 0.361 | 0.429 | -0.37 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Tim Wakefield | 46.0 | 3.33 | 7 | 0 | X | 0.94 |
| Jon Lester | 45.7 | 3.94 | 8 | 0 | X | 0.27 |
| Josh Beckett | 41.3 | 3.70 | 6 | 0 | X | 0.48 |
| Daisuke Matsuzaka | 40.7 | 2.43 | 7 | 0 | X | 1.67 |
| Clay Buchholz | 38.0 | 4.50 | 7 | 0 | X | -0.27 |
| Jonathan Papelbon | 17.0 | 1.59 | 0 | 16 | X | 1.04 |
| David Aardsma | 16.7 | 2.70 | 0 | 15 | X | 0.58 |
| Hideki Okajima | 15.0 | 0.60 | 0 | 15 | X | 1.26 |
| Manny Delcarmen | 13.3 | 6.75 | 0 | 17 | X | -0.79 |
| Javier Lopez | 13.0 | 3.46 | 0 | 16 | X | 0.22 |
| Julian Tavarez | 11.3 | 7.15 | 0 | 8 | X | -0.78 |
| Mike Timlin | 7.3 | 11.05 | 0 | 11 | X | -1.17 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.63 |
| Craig Hansen | 4.3 | 6.23 | 0 | 3 | X | -0.21 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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