| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 162 | 19 | 19 | 0.302 | 0.340 | 0.14 | 2B |
| Manny Ramirez | 151 | 24 | 24 | 0.316 | 0.397 | 1.45 | LF |
| Kevin Youkilis | 150 | 23 | 25 | 0.317 | 0.407 | 1.47 | 1B-3B |
| David Ortiz | 148 | 22 | 28 | 0.233 | 0.331 | 1.73 | DH |
| Julio Lugo | 128 | 10 | 8 | 0.293 | 0.352 | -1.15 | SS |
| Jacoby Ellsbury | 117 | 25 | 12 | 0.281 | 0.393 | 1.10 | CF-LF-RF |
| J.D. Drew | 115 | 22 | 16 | 0.281 | 0.391 | 1.25 | RF |
| Jason Varitek | 101 | 8 | 11 | 0.247 | 0.307 | -0.41 | CR |
| Coco Crisp | 75 | 7 | 6 | 0.290 | 0.307 | -0.42 | CF |
| Mike Lowell | 73 | 7 | 5 | 0.250 | 0.301 | -0.48 | 3B |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.07 | 1B-DH |
| Jed Lowrie | 44 | 4 | 6 | 0.263 | 0.295 | 0.00 | SS-3B |
| Kevin Cash | 42 | 2 | 4 | 0.361 | 0.429 | -0.37 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.11 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Tim Wakefield | 46.0 | 3.33 | 7 | 0 | X | 0.94 |
| Jon Lester | 45.7 | 3.94 | 8 | 0 | X | 0.28 |
| Daisuke Matsuzaka | 40.7 | 2.43 | 7 | 0 | X | 1.68 |
| Clay Buchholz | 38.0 | 4.50 | 7 | 0 | X | -0.26 |
| Josh Beckett | 34.3 | 4.19 | 5 | 0 | X | 0.01 |
| Jonathan Papelbon | 17.0 | 1.59 | 0 | 16 | X | 1.04 |
| David Aardsma | 16.7 | 2.70 | 0 | 15 | X | 0.58 |
| Hideki Okajima | 15.0 | 0.60 | 0 | 15 | X | 1.26 |
| Javier Lopez | 13.0 | 3.46 | 0 | 16 | X | 0.22 |
| Manny Delcarmen | 12.3 | 7.30 | 0 | 16 | X | -0.89 |
| Julian Tavarez | 11.3 | 7.15 | 0 | 8 | X | -0.78 |
| Mike Timlin | 7.3 | 11.05 | 0 | 11 | X | -1.17 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.63 |
| Craig Hansen | 3.3 | 8.10 | 0 | 2 | X | -0.30 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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