| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 161 | 19 | 18 | 0.297 | 0.335 | 0.04 | 2B |
| Manny Ramirez | 146 | 23 | 24 | 0.326 | 0.404 | 1.45 | LF |
| Kevin Youkilis | 145 | 21 | 22 | 0.314 | 0.407 | 1.05 | 1B-3B |
| David Ortiz | 143 | 22 | 27 | 0.226 | 0.329 | 1.73 | DH |
| Julio Lugo | 124 | 10 | 8 | 0.289 | 0.339 | -1.07 | SS |
| Jacoby Ellsbury | 112 | 23 | 12 | 0.275 | 0.393 | 1.00 | CF-LF-RF |
| J.D. Drew | 110 | 21 | 16 | 0.280 | 0.382 | 1.26 | RF |
| Jason Varitek | 96 | 7 | 11 | 0.258 | 0.312 | -0.40 | CR |
| Coco Crisp | 75 | 7 | 6 | 0.290 | 0.307 | -0.43 | CF |
| Mike Lowell | 68 | 5 | 2 | 0.222 | 0.279 | -0.89 | 3B |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.06 | 1B-DH |
| Kevin Cash | 42 | 2 | 4 | 0.361 | 0.429 | -0.37 | CR |
| Jed Lowrie | 40 | 4 | 5 | 0.286 | 0.325 | -0.01 | SS-3B |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.10 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.21 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Tim Wakefield | 46.0 | 3.33 | 7 | 0 | X | 0.93 |
| Jon Lester | 45.7 | 3.94 | 8 | 0 | X | 0.27 |
| Daisuke Matsuzaka | 40.7 | 2.43 | 7 | 0 | X | 1.67 |
| Josh Beckett | 34.3 | 4.19 | 5 | 0 | X | 0.00 |
| Clay Buchholz | 34.0 | 3.71 | 6 | 0 | X | 0.39 |
| Jonathan Papelbon | 16.3 | 1.65 | 0 | 15 | X | 0.97 |
| David Aardsma | 15.7 | 2.87 | 0 | 14 | X | 0.48 |
| Hideki Okajima | 14.0 | 0.64 | 0 | 14 | X | 1.16 |
| Manny Delcarmen | 12.3 | 7.30 | 0 | 16 | X | -0.89 |
| Javier Lopez | 12.0 | 3.75 | 0 | 15 | X | 0.12 |
| Julian Tavarez | 10.3 | 5.23 | 0 | 7 | X | -0.25 |
| Mike Timlin | 7.3 | 11.05 | 0 | 11 | X | -1.17 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.63 |
| Craig Hansen | 3.3 | 8.10 | 0 | 2 | X | -0.30 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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