| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 151 | 18 | 18 | 0.312 | 0.351 | 0.15 | 2B |
| Kevin Youkilis | 137 | 19 | 20 | 0.307 | 0.401 | 0.80 | 1B-3B |
| Manny Ramirez | 136 | 21 | 23 | 0.317 | 0.397 | 1.35 | LF |
| David Ortiz | 133 | 20 | 24 | 0.216 | 0.316 | 1.42 | DH |
| Julio Lugo | 116 | 10 | 8 | 0.290 | 0.336 | -0.90 | SS |
| Jacoby Ellsbury | 107 | 23 | 12 | 0.291 | 0.411 | 1.10 | CF-LF-RF |
| J.D. Drew | 102 | 20 | 15 | 0.271 | 0.382 | 1.22 | RF |
| Jason Varitek | 92 | 7 | 11 | 0.267 | 0.315 | -0.32 | CR |
| Coco Crisp | 70 | 7 | 5 | 0.308 | 0.329 | -0.42 | CF |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.05 | 1B-DH |
| Mike Lowell | 58 | 2 | 0 | 0.204 | 0.259 | -1.19 | 3B |
| Jed Lowrie | 40 | 4 | 5 | 0.286 | 0.325 | -0.02 | SS-3B |
| Kevin Cash | 38 | 2 | 3 | 0.312 | 0.395 | -0.39 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.10 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 45.7 | 3.94 | 8 | 0 | X | 0.29 |
| Tim Wakefield | 38.0 | 4.03 | 6 | 0 | X | 0.17 |
| Daisuke Matsuzaka | 35.7 | 2.52 | 6 | 0 | X | 1.41 |
| Josh Beckett | 34.3 | 4.19 | 5 | 0 | X | 0.02 |
| Clay Buchholz | 34.0 | 3.71 | 6 | 0 | X | 0.40 |
| David Aardsma | 15.7 | 2.87 | 0 | 14 | X | 0.49 |
| Jonathan Papelbon | 15.3 | 1.76 | 0 | 14 | X | 0.88 |
| Hideki Okajima | 12.7 | 0.71 | 0 | 13 | X | 1.04 |
| Manny Delcarmen | 12.3 | 7.30 | 0 | 16 | X | -0.89 |
| Javier Lopez | 12.0 | 3.75 | 0 | 15 | X | 0.13 |
| Julian Tavarez | 10.3 | 5.23 | 0 | 7 | X | -0.24 |
| Mike Timlin | 6.3 | 12.79 | 0 | 10 | X | -1.27 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
| Craig Hansen | 1.7 | 5.40 | 0 | 1 | X | -0.05 |
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