| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 146 | 17 | 17 | 0.313 | 0.349 | 0.06 | 2B |
| David Ortiz | 133 | 20 | 24 | 0.216 | 0.316 | 1.42 | DH |
| Kevin Youkilis | 132 | 17 | 16 | 0.291 | 0.394 | 0.29 | 1B-3B |
| Manny Ramirez | 131 | 21 | 22 | 0.322 | 0.405 | 1.37 | LF |
| Julio Lugo | 112 | 9 | 8 | 0.288 | 0.330 | -0.91 | SS |
| Jacoby Ellsbury | 102 | 21 | 12 | 0.293 | 0.412 | 1.01 | CF-LF-RF |
| J.D. Drew | 98 | 20 | 15 | 0.280 | 0.388 | 1.32 | RF |
| Jason Varitek | 88 | 7 | 11 | 0.256 | 0.307 | -0.22 | CR |
| Coco Crisp | 66 | 6 | 5 | 0.290 | 0.303 | -0.43 | CF |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.05 | 1B-DH |
| Mike Lowell | 54 | 2 | 0 | 0.220 | 0.278 | -1.09 | 3B |
| Jed Lowrie | 40 | 4 | 5 | 0.286 | 0.325 | -0.02 | SS-3B |
| Kevin Cash | 38 | 2 | 3 | 0.312 | 0.395 | -0.39 | CR |
| Brandon Moss | 22 | 3 | 3 | 0.286 | 0.318 | 0.10 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 39.7 | 4.31 | 7 | 0 | X | -0.09 |
| Tim Wakefield | 38.0 | 4.03 | 6 | 0 | X | 0.16 |
| Daisuke Matsuzaka | 35.7 | 2.52 | 6 | 0 | X | 1.41 |
| Josh Beckett | 34.3 | 4.19 | 5 | 0 | X | 0.01 |
| Clay Buchholz | 34.0 | 3.71 | 6 | 0 | X | 0.40 |
| David Aardsma | 15.7 | 2.87 | 0 | 14 | X | 0.49 |
| Jonathan Papelbon | 14.0 | 1.93 | 0 | 13 | X | 0.75 |
| Javier Lopez | 12.0 | 3.75 | 0 | 15 | X | 0.13 |
| Manny Delcarmen | 12.0 | 6.00 | 0 | 15 | X | -0.50 |
| Hideki Okajima | 11.3 | 0.79 | 0 | 12 | X | 0.90 |
| Julian Tavarez | 10.3 | 5.23 | 0 | 7 | X | -0.24 |
| Mike Timlin | 6.3 | 12.79 | 0 | 10 | X | -1.27 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
| Craig Hansen | 1.7 | 5.40 | 0 | 1 | X | -0.05 |
_