| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Dustin Pedroia | 136 | 14 | 13 | 0.290 | 0.331 | -0.45 | 2B |
| Kevin Youkilis | 123 | 16 | 15 | 0.295 | 0.382 | 0.29 | 1B-3B |
| David Ortiz | 123 | 18 | 21 | 0.196 | 0.301 | 1.13 | DH |
| Manny Ramirez | 121 | 19 | 20 | 0.336 | 0.413 | 1.18 | LF |
| Julio Lugo | 103 | 7 | 7 | 0.281 | 0.320 | -1.02 | SS |
| J.D. Drew | 93 | 18 | 13 | 0.269 | 0.376 | 1.01 | RF |
| Jacoby Ellsbury | 92 | 18 | 11 | 0.280 | 0.391 | 0.82 | CF-LF-RF |
| Jason Varitek | 79 | 6 | 7 | 0.243 | 0.291 | -0.54 | CR |
| Coco Crisp | 66 | 6 | 5 | 0.290 | 0.303 | -0.44 | CF |
| Sean Casey | 59 | 6 | 8 | 0.346 | 0.424 | 0.05 | 1B-DH |
| Mike Lowell | 45 | 1 | 0 | 0.195 | 0.267 | -0.98 | 3B |
| Jed Lowrie | 40 | 4 | 5 | 0.286 | 0.325 | -0.02 | SS-3B |
| Kevin Cash | 38 | 2 | 3 | 0.312 | 0.395 | -0.39 | CR |
| Brandon Moss | 18 | 1 | 2 | 0.235 | 0.278 | -0.12 | LF-RF |
| Joe Thurston | 9 | 0 | 0 | 0.000 | 0.111 | -0.22 | X |
| Alex Cora | 5 | 0 | 0 | 1.000 | 1.000 | -0.12 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Jon Lester | 39.7 | 4.31 | 7 | 0 | X | -0.10 |
| Tim Wakefield | 38.0 | 4.03 | 6 | 0 | X | 0.16 |
| Daisuke Matsuzaka | 35.7 | 2.52 | 6 | 0 | X | 1.40 |
| Clay Buchholz | 28.7 | 4.08 | 5 | 0 | X | 0.08 |
| Josh Beckett | 26.3 | 4.10 | 4 | 0 | X | 0.07 |
| David Aardsma | 14.7 | 3.07 | 0 | 13 | X | 0.39 |
| Jonathan Papelbon | 13.0 | 2.08 | 0 | 12 | X | 0.65 |
| Manny Delcarmen | 11.7 | 6.17 | 0 | 14 | X | -0.53 |
| Javier Lopez | 10.7 | 4.22 | 0 | 14 | X | 0.00 |
| Hideki Okajima | 10.3 | 0.87 | 0 | 11 | X | 0.80 |
| Julian Tavarez | 10.3 | 5.23 | 0 | 7 | X | -0.25 |
| Mike Timlin | 6.3 | 12.79 | 0 | 10 | X | -1.27 |
| Justin Masterson | 6.0 | 1.50 | 1 | 0 | X | 0.38 |
| Bryan Corey | 6.0 | 10.50 | 0 | 7 | X | -0.88 |
| David Pauley | 4.3 | 10.38 | 1 | 0 | X | -0.62 |
| Craig Hansen | 1.7 | 5.40 | 0 | 1 | X | -0.05 |
| Kyle Snyder | 1.7 | 21.60 | 0 | 2 | X | -0.68 |
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