| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 667 | 116 | 118 | 0.332 | 0.445 | 8.01 | DH |
| Mike Lowell | 653 | 79 | 120 | 0.324 | 0.378 | 4.68 | 3B |
| Julio Lugo | 630 | 70 | 72 | 0.236 | 0.290 | -0.73 | SS |
| Kevin Youkilis | 625 | 86 | 83 | 0.288 | 0.390 | 2.23 | 1B-3B |
| Coco Crisp | 591 | 83 | 60 | 0.268 | 0.325 | 0.34 | CF |
| Dustin Pedroia | 581 | 89 | 50 | 0.317 | 0.377 | 0.17 | 2B |
| Manny Ramirez | 569 | 87 | 87 | 0.295 | 0.388 | 4.14 | LF-DH |
| J.D. Drew | 552 | 83 | 65 | 0.270 | 0.373 | 1.83 | RF |
| Jason Varitek | 518 | 58 | 68 | 0.255 | 0.367 | 0.37 | CR |
| Alex Cora | 232 | 29 | 18 | 0.246 | 0.289 | -0.83 | 2B-SS |
| Eric Hinske | 218 | 25 | 22 | 0.204 | 0.317 | -0.48 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.60 | LF |
| Doug Mirabelli | 127 | 10 | 16 | 0.202 | 0.276 | -0.42 | CR |
| Jacoby Ellsbury | 127 | 19 | 18 | 0.353 | 0.394 | 0.73 | LF-CF |
| Bobby Kielty | 61 | 6 | 9 | 0.231 | 0.295 | 0.06 | X |
| Kevin Cash | 33 | 2 | 4 | 0.111 | 0.242 | -0.19 | CR |
| Brandon Moss | 29 | 4 | 1 | 0.280 | 0.379 | -0.20 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Royce Clayton | 6 | 0 | 0 | 0.000 | 0.000 | -0.15 | SS |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 204.7 | 4.35 | 32 | 0 | X | 0.63 |
| Josh Beckett | 200.7 | 3.27 | 30 | 0 | X | 5.67 |
| Tim Wakefield | 189.0 | 4.76 | 31 | 0 | X | -1.22 |
| Curt Schilling | 151.0 | 3.87 | 24 | 0 | X | 2.15 |
| Julian Tavarez | 134.7 | 5.15 | 23 | 11 | X | -2.08 |
| Hideki Okajima | 69.0 | 2.22 | 0 | 66 | X | 3.65 |
| Jon Lester | 63.0 | 4.57 | 11 | 1 | X | -0.13 |
| Jonathan Papelbon | 58.3 | 1.85 | 0 | 59 | X | 3.58 |
| Mike Timlin | 55.3 | 3.42 | 0 | 50 | X | 1.38 |
| Kyle Snyder | 54.3 | 3.81 | 0 | 46 | X | 0.86 |
| Manny Delcarmen | 44.0 | 2.25 | 0 | 44 | X | 2.29 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.72 |
| Javier Lopez | 40.7 | 3.10 | 0 | 61 | X | 1.32 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.43 |
| Clay Buchholz | 22.7 | 1.59 | 3 | 1 | X | 1.53 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Eric Gagne | 18.7 | 6.75 | 0 | 20 | X | -0.99 |
| Bryan Corey | 9.3 | 1.93 | 0 | 9 | X | 0.56 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
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