| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 664 | 116 | 118 | 0.333 | 0.446 | 8.08 | DH |
| Mike Lowell | 646 | 77 | 118 | 0.325 | 0.379 | 4.43 | 3B |
| Julio Lugo | 626 | 69 | 72 | 0.236 | 0.289 | -0.74 | SS |
| Kevin Youkilis | 618 | 86 | 82 | 0.286 | 0.390 | 2.29 | 1B-3B |
| Coco Crisp | 584 | 82 | 60 | 0.268 | 0.325 | 0.41 | CF |
| Dustin Pedroia | 578 | 89 | 50 | 0.317 | 0.377 | 0.24 | 2B |
| Manny Ramirez | 562 | 87 | 86 | 0.295 | 0.388 | 4.21 | LF-DH |
| J.D. Drew | 548 | 81 | 62 | 0.266 | 0.370 | 1.41 | RF |
| Jason Varitek | 515 | 57 | 67 | 0.254 | 0.365 | 0.23 | CR |
| Alex Cora | 226 | 28 | 18 | 0.243 | 0.283 | -0.78 | 2B-SS |
| Eric Hinske | 217 | 25 | 22 | 0.205 | 0.318 | -0.45 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.60 | LF |
| Doug Mirabelli | 121 | 10 | 16 | 0.213 | 0.289 | -0.27 | CR |
| Jacoby Ellsbury | 119 | 19 | 18 | 0.343 | 0.387 | 0.93 | LF-CF |
| Bobby Kielty | 59 | 6 | 9 | 0.240 | 0.305 | 0.11 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 28 | 4 | 1 | 0.280 | 0.357 | -0.17 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 204.7 | 4.35 | 32 | 0 | X | 0.64 |
| Josh Beckett | 200.7 | 3.27 | 30 | 0 | X | 5.68 |
| Tim Wakefield | 182.0 | 4.80 | 30 | 0 | X | -1.31 |
| Curt Schilling | 151.0 | 3.87 | 24 | 0 | X | 2.16 |
| Julian Tavarez | 131.7 | 5.06 | 22 | 11 | X | -1.75 |
| Hideki Okajima | 68.0 | 2.25 | 0 | 65 | X | 3.55 |
| Jon Lester | 61.0 | 4.72 | 11 | 0 | X | -0.33 |
| Jonathan Papelbon | 57.3 | 1.88 | 0 | 58 | X | 3.48 |
| Kyle Snyder | 54.3 | 3.81 | 0 | 46 | X | 0.86 |
| Mike Timlin | 54.3 | 3.48 | 0 | 49 | X | 1.28 |
| Manny Delcarmen | 43.0 | 2.30 | 0 | 43 | X | 2.19 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.72 |
| Javier Lopez | 39.7 | 3.18 | 0 | 60 | X | 1.21 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.43 |
| Clay Buchholz | 22.7 | 1.59 | 3 | 1 | X | 1.53 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Eric Gagne | 17.7 | 7.13 | 0 | 19 | X | -1.09 |
| Bryan Corey | 9.3 | 1.93 | 0 | 9 | X | 0.56 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
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