| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 655 | 112 | 115 | 0.325 | 0.440 | 7.56 | DH |
| Mike Lowell | 637 | 75 | 116 | 0.326 | 0.381 | 4.23 | 3B |
| Julio Lugo | 619 | 69 | 72 | 0.237 | 0.291 | -0.57 | SS |
| Kevin Youkilis | 613 | 86 | 81 | 0.287 | 0.392 | 2.31 | 1B-3B |
| Coco Crisp | 584 | 82 | 60 | 0.268 | 0.325 | 0.40 | CF |
| Dustin Pedroia | 569 | 89 | 50 | 0.317 | 0.378 | 0.46 | 2B |
| Manny Ramirez | 555 | 85 | 86 | 0.297 | 0.391 | 4.17 | LF-DH |
| J.D. Drew | 539 | 81 | 60 | 0.266 | 0.369 | 1.41 | RF |
| Jason Varitek | 507 | 56 | 66 | 0.255 | 0.365 | 0.21 | CR |
| Alex Cora | 226 | 28 | 18 | 0.243 | 0.283 | -0.78 | 2B-SS |
| Eric Hinske | 213 | 25 | 22 | 0.204 | 0.319 | -0.36 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.60 | LF |
| Doug Mirabelli | 121 | 10 | 16 | 0.213 | 0.289 | -0.28 | CR |
| Jacoby Ellsbury | 114 | 19 | 18 | 0.359 | 0.404 | 1.05 | LF-CF |
| Bobby Kielty | 56 | 6 | 9 | 0.255 | 0.321 | 0.18 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 27 | 4 | 1 | 0.250 | 0.333 | -0.15 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 196.7 | 4.44 | 31 | 0 | X | 0.25 |
| Josh Beckett | 194.7 | 3.14 | 29 | 0 | X | 6.13 |
| Tim Wakefield | 182.0 | 4.80 | 30 | 0 | X | -1.29 |
| Curt Schilling | 151.0 | 3.87 | 24 | 0 | X | 2.18 |
| Julian Tavarez | 131.7 | 5.06 | 22 | 11 | X | -1.74 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.45 |
| Jon Lester | 61.0 | 4.72 | 11 | 0 | X | -0.32 |
| Jonathan Papelbon | 56.3 | 1.92 | 0 | 57 | X | 3.39 |
| Kyle Snyder | 54.3 | 3.81 | 0 | 46 | X | 0.87 |
| Mike Timlin | 54.3 | 3.48 | 0 | 49 | X | 1.29 |
| Manny Delcarmen | 42.0 | 2.36 | 0 | 42 | X | 2.09 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.73 |
| Javier Lopez | 39.7 | 3.18 | 0 | 60 | X | 1.22 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.43 |
| Clay Buchholz | 22.7 | 1.59 | 3 | 1 | X | 1.54 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.70 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.63 |
| Eric Gagne | 17.7 | 7.13 | 0 | 19 | X | -1.09 |
| Bryan Corey | 8.3 | 2.16 | 0 | 8 | X | 0.45 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
_