| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 645 | 108 | 113 | 0.321 | 0.436 | 7.20 | DH |
| Mike Lowell | 627 | 74 | 110 | 0.324 | 0.380 | 3.76 | 3B |
| Julio Lugo | 610 | 68 | 72 | 0.239 | 0.292 | -0.44 | SS |
| Kevin Youkilis | 607 | 86 | 81 | 0.288 | 0.392 | 2.47 | 1B-3B |
| Coco Crisp | 584 | 82 | 60 | 0.268 | 0.325 | 0.42 | CF |
| Dustin Pedroia | 558 | 84 | 49 | 0.315 | 0.376 | 0.12 | 2B |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.73 | LF-DH |
| J.D. Drew | 529 | 80 | 58 | 0.261 | 0.365 | 1.36 | RF |
| Jason Varitek | 497 | 56 | 66 | 0.257 | 0.362 | 0.48 | CR |
| Alex Cora | 226 | 28 | 18 | 0.243 | 0.283 | -0.78 | 2B-SS |
| Eric Hinske | 210 | 25 | 21 | 0.207 | 0.319 | -0.38 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.59 | LF |
| Doug Mirabelli | 121 | 10 | 16 | 0.213 | 0.289 | -0.27 | CR |
| Jacoby Ellsbury | 104 | 19 | 15 | 0.372 | 0.423 | 0.99 | LF-CF |
| Bobby Kielty | 54 | 6 | 8 | 0.261 | 0.333 | 0.13 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 26 | 3 | 0 | 0.217 | 0.308 | -0.33 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 196.7 | 4.44 | 31 | 0 | X | 0.20 |
| Josh Beckett | 194.7 | 3.14 | 29 | 0 | X | 6.08 |
| Tim Wakefield | 182.0 | 4.80 | 30 | 0 | X | -1.34 |
| Curt Schilling | 145.0 | 3.97 | 23 | 0 | X | 1.72 |
| Julian Tavarez | 130.7 | 5.03 | 22 | 10 | X | -1.67 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.44 |
| Jon Lester | 56.7 | 4.45 | 10 | 0 | X | 0.05 |
| Jonathan Papelbon | 56.0 | 1.93 | 0 | 56 | X | 3.34 |
| Kyle Snyder | 53.3 | 3.88 | 0 | 45 | X | 0.75 |
| Mike Timlin | 53.0 | 3.57 | 0 | 48 | X | 1.13 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.72 |
| Manny Delcarmen | 41.0 | 2.41 | 0 | 41 | X | 1.98 |
| Javier Lopez | 39.3 | 3.20 | 0 | 59 | X | 1.17 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.43 |
| Clay Buchholz | 22.7 | 1.59 | 3 | 1 | X | 1.53 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Eric Gagne | 16.0 | 7.88 | 0 | 17 | X | -1.27 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 7.3 | 0.00 | 0 | 7 | X | 0.77 |
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