| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 631 | 107 | 107 | 0.319 | 0.434 | 6.82 | DH |
| Mike Lowell | 613 | 71 | 109 | 0.327 | 0.382 | 3.70 | 3B |
| Kevin Youkilis | 607 | 86 | 81 | 0.288 | 0.392 | 2.48 | 1B-3B |
| Julio Lugo | 598 | 66 | 70 | 0.239 | 0.293 | -0.55 | SS |
| Coco Crisp | 572 | 81 | 59 | 0.270 | 0.327 | 0.51 | CF |
| Dustin Pedroia | 548 | 82 | 49 | 0.318 | 0.378 | 0.16 | 2B |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.73 | LF-DH |
| J.D. Drew | 521 | 78 | 54 | 0.261 | 0.365 | 0.94 | RF |
| Jason Varitek | 487 | 54 | 63 | 0.252 | 0.357 | 0.21 | CR |
| Alex Cora | 222 | 26 | 17 | 0.237 | 0.279 | -0.99 | 2B-SS |
| Eric Hinske | 197 | 23 | 21 | 0.216 | 0.330 | -0.27 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.59 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.20 | CR |
| Jacoby Ellsbury | 90 | 16 | 14 | 0.366 | 0.411 | 0.92 | LF-CF |
| Bobby Kielty | 49 | 6 | 8 | 0.279 | 0.327 | 0.25 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 25 | 3 | 0 | 0.182 | 0.280 | -0.31 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 190.0 | 4.36 | 30 | 0 | X | 0.53 |
| Josh Beckett | 188.7 | 3.20 | 28 | 0 | X | 5.64 |
| Tim Wakefield | 177.0 | 4.73 | 29 | 0 | X | -1.04 |
| Curt Schilling | 145.0 | 3.97 | 23 | 0 | X | 1.71 |
| Julian Tavarez | 130.3 | 4.97 | 22 | 9 | X | -1.50 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.43 |
| Jon Lester | 56.7 | 4.45 | 10 | 0 | X | 0.04 |
| Jonathan Papelbon | 55.0 | 1.96 | 0 | 55 | X | 3.23 |
| Kyle Snyder | 53.3 | 3.88 | 0 | 45 | X | 0.74 |
| Mike Timlin | 51.7 | 3.66 | 0 | 46 | X | 0.99 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.71 |
| Manny Delcarmen | 39.7 | 2.50 | 0 | 40 | X | 1.83 |
| Javier Lopez | 38.7 | 3.03 | 0 | 57 | X | 1.31 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.44 |
| Clay Buchholz | 22.7 | 1.59 | 3 | 1 | X | 1.53 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Eric Gagne | 14.0 | 9.00 | 0 | 15 | X | -1.48 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 5.7 | 0.00 | 0 | 6 | X | 0.59 |
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