| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 627 | 107 | 107 | 0.321 | 0.435 | 6.92 | DH |
| Mike Lowell | 609 | 71 | 109 | 0.329 | 0.384 | 3.79 | 3B |
| Kevin Youkilis | 607 | 86 | 81 | 0.288 | 0.392 | 2.48 | 1B-3B |
| Julio Lugo | 595 | 66 | 70 | 0.241 | 0.294 | -0.48 | SS |
| Coco Crisp | 572 | 81 | 59 | 0.270 | 0.327 | 0.51 | CF |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.73 | LF-DH |
| Dustin Pedroia | 544 | 82 | 49 | 0.320 | 0.381 | 0.26 | 2B |
| J.D. Drew | 517 | 77 | 53 | 0.261 | 0.366 | 0.82 | RF |
| Jason Varitek | 483 | 54 | 63 | 0.254 | 0.358 | 0.30 | CR |
| Alex Cora | 222 | 26 | 17 | 0.237 | 0.279 | -0.99 | 2B-SS |
| Eric Hinske | 193 | 23 | 21 | 0.215 | 0.332 | -0.17 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.59 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.20 | CR |
| Jacoby Ellsbury | 86 | 16 | 14 | 0.367 | 0.407 | 1.02 | LF-CF |
| Bobby Kielty | 46 | 6 | 8 | 0.286 | 0.304 | 0.33 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 25 | 3 | 0 | 0.182 | 0.280 | -0.31 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 190.0 | 4.36 | 30 | 0 | X | 0.54 |
| Josh Beckett | 188.7 | 3.20 | 28 | 0 | X | 5.65 |
| Tim Wakefield | 177.0 | 4.73 | 29 | 0 | X | -1.03 |
| Curt Schilling | 145.0 | 3.97 | 23 | 0 | X | 1.72 |
| Julian Tavarez | 130.3 | 4.97 | 22 | 9 | X | -1.50 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.43 |
| Jon Lester | 56.7 | 4.45 | 10 | 0 | X | 0.04 |
| Jonathan Papelbon | 54.3 | 1.82 | 0 | 54 | X | 3.37 |
| Kyle Snyder | 53.3 | 3.88 | 0 | 45 | X | 0.74 |
| Mike Timlin | 51.3 | 3.16 | 0 | 45 | X | 1.59 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.72 |
| Javier Lopez | 38.3 | 3.05 | 0 | 56 | X | 1.28 |
| Manny Delcarmen | 38.3 | 2.58 | 0 | 39 | X | 1.70 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.44 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Clay Buchholz | 18.0 | 1.50 | 2 | 1 | X | 1.25 |
| Eric Gagne | 14.0 | 9.00 | 0 | 15 | X | -1.48 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 5.0 | 0.00 | 0 | 5 | X | 0.52 |
_