| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 623 | 107 | 106 | 0.322 | 0.437 | 6.91 | DH |
| Kevin Youkilis | 607 | 86 | 81 | 0.288 | 0.392 | 2.48 | 1B-3B |
| Mike Lowell | 605 | 70 | 109 | 0.329 | 0.383 | 3.79 | 3B |
| Julio Lugo | 591 | 65 | 69 | 0.239 | 0.293 | -0.59 | SS |
| Coco Crisp | 572 | 81 | 59 | 0.270 | 0.327 | 0.51 | CF |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.73 | LF-DH |
| Dustin Pedroia | 540 | 81 | 49 | 0.321 | 0.381 | 0.26 | 2B |
| J.D. Drew | 513 | 77 | 53 | 0.260 | 0.365 | 0.92 | RF |
| Jason Varitek | 479 | 54 | 62 | 0.251 | 0.357 | 0.30 | CR |
| Alex Cora | 222 | 26 | 17 | 0.237 | 0.279 | -0.99 | 2B-SS |
| Eric Hinske | 189 | 23 | 21 | 0.220 | 0.339 | -0.07 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.59 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.20 | CR |
| Jacoby Ellsbury | 81 | 16 | 14 | 0.378 | 0.420 | 1.14 | LF-CF |
| Bobby Kielty | 46 | 6 | 8 | 0.286 | 0.304 | 0.33 | X |
| Kevin Cash | 32 | 2 | 4 | 0.115 | 0.250 | -0.16 | CR |
| Brandon Moss | 21 | 3 | 0 | 0.211 | 0.286 | -0.21 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 190.0 | 4.36 | 30 | 0 | X | 0.53 |
| Josh Beckett | 188.7 | 3.20 | 28 | 0 | X | 5.64 |
| Tim Wakefield | 177.0 | 4.73 | 29 | 0 | X | -1.03 |
| Curt Schilling | 145.0 | 3.97 | 23 | 0 | X | 1.71 |
| Julian Tavarez | 130.3 | 4.97 | 22 | 9 | X | -1.50 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.43 |
| Jonathan Papelbon | 54.3 | 1.82 | 0 | 54 | X | 3.37 |
| Kyle Snyder | 53.3 | 3.88 | 0 | 45 | X | 0.74 |
| Mike Timlin | 51.3 | 3.16 | 0 | 45 | X | 1.58 |
| Jon Lester | 50.0 | 4.86 | 9 | 0 | X | -0.45 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.71 |
| Javier Lopez | 38.3 | 3.05 | 0 | 56 | X | 1.28 |
| Manny Delcarmen | 38.0 | 2.61 | 0 | 38 | X | 1.66 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.44 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Clay Buchholz | 18.0 | 1.50 | 2 | 1 | X | 1.25 |
| Eric Gagne | 13.0 | 7.62 | 0 | 14 | X | -0.95 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 5.0 | 0.00 | 0 | 5 | X | 0.52 |
_