| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 619 | 107 | 106 | 0.324 | 0.439 | 7.06 | DH |
| Kevin Youkilis | 607 | 86 | 81 | 0.288 | 0.392 | 2.52 | 1B-3B |
| Mike Lowell | 601 | 70 | 108 | 0.330 | 0.384 | 3.83 | 3B |
| Julio Lugo | 591 | 65 | 69 | 0.239 | 0.293 | -0.55 | SS |
| Coco Crisp | 569 | 81 | 59 | 0.271 | 0.329 | 0.63 | CF |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.77 | LF-DH |
| Dustin Pedroia | 536 | 81 | 49 | 0.322 | 0.382 | 0.39 | 2B |
| J.D. Drew | 510 | 77 | 53 | 0.262 | 0.367 | 1.04 | RF |
| Jason Varitek | 479 | 54 | 62 | 0.251 | 0.357 | 0.33 | CR |
| Alex Cora | 219 | 26 | 17 | 0.236 | 0.279 | -0.90 | 2B-SS |
| Eric Hinske | 186 | 23 | 21 | 0.224 | 0.344 | 0.02 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.58 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.19 | CR |
| Jacoby Ellsbury | 77 | 15 | 14 | 0.371 | 0.416 | 1.14 | LF-CF |
| Bobby Kielty | 46 | 6 | 8 | 0.286 | 0.304 | 0.33 | X |
| Kevin Cash | 30 | 2 | 4 | 0.125 | 0.267 | -0.11 | CR |
| Brandon Moss | 20 | 3 | 0 | 0.222 | 0.300 | -0.18 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 190.0 | 4.36 | 30 | 0 | X | 0.50 |
| Josh Beckett | 188.7 | 3.20 | 28 | 0 | X | 5.61 |
| Tim Wakefield | 171.0 | 4.68 | 28 | 0 | X | -0.86 |
| Curt Schilling | 145.0 | 3.97 | 23 | 0 | X | 1.68 |
| Julian Tavarez | 130.3 | 4.97 | 22 | 9 | X | -1.53 |
| Hideki Okajima | 67.0 | 2.28 | 0 | 64 | X | 3.42 |
| Jonathan Papelbon | 54.3 | 1.82 | 0 | 54 | X | 3.36 |
| Kyle Snyder | 52.3 | 3.78 | 0 | 44 | X | 0.84 |
| Mike Timlin | 51.3 | 3.16 | 0 | 45 | X | 1.57 |
| Jon Lester | 50.0 | 4.86 | 9 | 0 | X | -0.46 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.71 |
| Javier Lopez | 38.3 | 3.05 | 0 | 56 | X | 1.27 |
| Manny Delcarmen | 38.0 | 2.61 | 0 | 38 | X | 1.65 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.44 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Clay Buchholz | 18.0 | 1.50 | 2 | 1 | X | 1.25 |
| Eric Gagne | 13.0 | 7.62 | 0 | 14 | X | -0.95 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 4.0 | 0.00 | 0 | 4 | X | 0.42 |
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