| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 599 | 104 | 99 | 0.320 | 0.434 | 6.48 | DH |
| Kevin Youkilis | 595 | 84 | 80 | 0.289 | 0.392 | 2.48 | 1B-3B |
| Mike Lowell | 587 | 68 | 103 | 0.326 | 0.380 | 3.41 | 3B |
| Julio Lugo | 572 | 61 | 68 | 0.240 | 0.292 | -0.62 | SS |
| Coco Crisp | 556 | 79 | 58 | 0.271 | 0.329 | 0.61 | CF |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.75 | LF-DH |
| Dustin Pedroia | 516 | 77 | 47 | 0.325 | 0.386 | 0.24 | 2B |
| J.D. Drew | 492 | 76 | 51 | 0.259 | 0.362 | 1.15 | RF |
| Jason Varitek | 461 | 53 | 62 | 0.261 | 0.364 | 0.66 | CR |
| Alex Cora | 219 | 26 | 17 | 0.236 | 0.279 | -0.91 | 2B-SS |
| Eric Hinske | 173 | 21 | 20 | 0.222 | 0.347 | 0.02 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.59 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.19 | CR |
| Jacoby Ellsbury | 65 | 12 | 10 | 0.373 | 0.415 | 0.70 | LF-CF |
| Bobby Kielty | 41 | 5 | 8 | 0.297 | 0.317 | 0.35 | X |
| Kevin Cash | 30 | 2 | 4 | 0.125 | 0.267 | -0.11 | CR |
| Brandon Moss | 16 | 3 | 0 | 0.214 | 0.312 | -0.08 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 184.3 | 4.39 | 29 | 0 | X | 0.33 |
| Josh Beckett | 181.7 | 3.27 | 27 | 0 | X | 5.09 |
| Tim Wakefield | 171.0 | 4.68 | 28 | 0 | X | -0.85 |
| Curt Schilling | 137.3 | 3.93 | 22 | 0 | X | 1.72 |
| Julian Tavarez | 127.3 | 5.09 | 22 | 8 | X | -1.84 |
| Hideki Okajima | 66.3 | 1.76 | 0 | 62 | X | 4.19 |
| Jonathan Papelbon | 52.3 | 1.55 | 0 | 52 | X | 3.57 |
| Kyle Snyder | 52.3 | 3.78 | 0 | 44 | X | 0.84 |
| Mike Timlin | 50.0 | 3.24 | 0 | 43 | X | 1.43 |
| Jon Lester | 46.3 | 4.47 | 8 | 0 | X | 0.00 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.71 |
| Javier Lopez | 37.7 | 3.11 | 0 | 54 | X | 1.20 |
| Manny Delcarmen | 36.7 | 2.70 | 0 | 36 | X | 1.51 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.44 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.69 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.62 |
| Clay Buchholz | 18.0 | 1.50 | 2 | 1 | X | 1.25 |
| Eric Gagne | 11.0 | 9.00 | 0 | 12 | X | -1.16 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 3.0 | 0.00 | 0 | 3 | X | 0.31 |
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