| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 593 | 102 | 98 | 0.319 | 0.433 | 6.33 | DH |
| Kevin Youkilis | 586 | 82 | 77 | 0.289 | 0.392 | 2.20 | 1B-3B |
| Mike Lowell | 578 | 65 | 103 | 0.324 | 0.379 | 3.34 | 3B |
| Julio Lugo | 563 | 60 | 66 | 0.239 | 0.291 | -0.70 | SS |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.77 | LF-DH |
| Coco Crisp | 547 | 77 | 56 | 0.269 | 0.327 | 0.43 | CF |
| Dustin Pedroia | 506 | 76 | 45 | 0.325 | 0.387 | 0.19 | 2B |
| J.D. Drew | 487 | 72 | 50 | 0.254 | 0.357 | 0.76 | RF |
| Jason Varitek | 457 | 53 | 62 | 0.262 | 0.363 | 0.77 | CR |
| Alex Cora | 216 | 26 | 17 | 0.240 | 0.282 | -0.83 | 2B-SS |
| Eric Hinske | 173 | 21 | 20 | 0.222 | 0.347 | 0.02 | 1B-LF-RF |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.58 | LF |
| Doug Mirabelli | 118 | 10 | 16 | 0.219 | 0.297 | -0.19 | CR |
| Jacoby Ellsbury | 56 | 11 | 8 | 0.373 | 0.411 | 0.61 | LF-CF |
| Bobby Kielty | 38 | 5 | 8 | 0.294 | 0.316 | 0.42 | X |
| Kevin Cash | 25 | 2 | 1 | 0.100 | 0.280 | -0.30 | CR |
| Brandon Moss | 16 | 3 | 0 | 0.214 | 0.312 | -0.08 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Royce Clayton | 1 | 0 | 0 | 0.000 | 0.000 | -0.02 | SS |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 184.3 | 4.39 | 29 | 0 | X | 0.29 |
| Josh Beckett | 181.7 | 3.27 | 27 | 0 | X | 5.06 |
| Tim Wakefield | 168.0 | 4.39 | 27 | 0 | X | 0.27 |
| Curt Schilling | 131.3 | 4.04 | 21 | 0 | X | 1.29 |
| Julian Tavarez | 127.3 | 5.09 | 22 | 8 | X | -1.86 |
| Hideki Okajima | 66.3 | 1.76 | 0 | 62 | X | 4.18 |
| Jonathan Papelbon | 52.3 | 1.55 | 0 | 52 | X | 3.56 |
| Kyle Snyder | 50.7 | 3.55 | 0 | 43 | X | 1.08 |
| Mike Timlin | 47.7 | 3.40 | 0 | 41 | X | 1.18 |
| Jon Lester | 46.3 | 4.47 | 8 | 0 | X | -0.01 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.70 |
| Javier Lopez | 36.7 | 3.19 | 0 | 52 | X | 1.09 |
| Manny Delcarmen | 35.7 | 2.78 | 0 | 35 | X | 1.40 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.45 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.68 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.61 |
| Clay Buchholz | 18.0 | 1.50 | 2 | 1 | X | 1.24 |
| Eric Gagne | 10.0 | 9.00 | 0 | 11 | X | -1.06 |
| Devern Hansack | 7.7 | 4.70 | 1 | 2 | X | -0.04 |
| Bryan Corey | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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