| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 562 | 78 | 75 | 0.289 | 0.391 | 2.23 | 1B-3B |
| David Ortiz | 560 | 98 | 93 | 0.318 | 0.434 | 6.27 | DH |
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.84 | LF-DH |
| Mike Lowell | 547 | 63 | 97 | 0.329 | 0.382 | 3.34 | 3B |
| Julio Lugo | 536 | 57 | 63 | 0.237 | 0.289 | -0.59 | SS |
| Coco Crisp | 519 | 72 | 49 | 0.266 | 0.328 | -0.07 | CF |
| Dustin Pedroia | 477 | 71 | 42 | 0.324 | 0.390 | 0.12 | 2B |
| J.D. Drew | 459 | 66 | 47 | 0.254 | 0.355 | 0.57 | RF |
| Jason Varitek | 432 | 50 | 57 | 0.259 | 0.361 | 0.60 | CR |
| Alex Cora | 208 | 26 | 17 | 0.250 | 0.293 | -0.60 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.56 | LF |
| Eric Hinske | 168 | 20 | 20 | 0.213 | 0.333 | 0.06 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Bobby Kielty | 34 | 5 | 8 | 0.333 | 0.353 | 0.53 | X |
| Jacoby Ellsbury | 26 | 5 | 4 | 0.391 | 0.462 | 0.31 | LF-CF |
| Kevin Cash | 22 | 2 | 1 | 0.118 | 0.318 | -0.23 | CR |
| Brandon Moss | 15 | 2 | 0 | 0.154 | 0.267 | -0.16 | LF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 176.3 | 3.83 | 27 | 0 | X | 2.52 |
| Josh Beckett | 166.7 | 3.29 | 25 | 0 | X | 4.46 |
| Tim Wakefield | 164.3 | 4.16 | 26 | 0 | X | 1.07 |
| Julian Tavarez | 126.0 | 5.00 | 22 | 7 | X | -1.64 |
| Curt Schilling | 125.3 | 4.02 | 20 | 0 | X | 1.23 |
| Hideki Okajima | 63.3 | 1.56 | 0 | 59 | X | 4.25 |
| Kyle Snyder | 49.3 | 3.65 | 0 | 42 | X | 0.91 |
| Jonathan Papelbon | 48.3 | 1.68 | 0 | 48 | X | 3.12 |
| Mike Timlin | 46.0 | 3.52 | 0 | 39 | X | 0.99 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.68 |
| Jon Lester | 39.3 | 5.26 | 7 | 0 | X | -0.75 |
| Javier Lopez | 35.7 | 2.78 | 0 | 50 | X | 1.39 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.47 |
| Manny Delcarmen | 32.7 | 2.48 | 0 | 32 | X | 1.49 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Clay Buchholz | 15.0 | 1.80 | 2 | 0 | X | 0.92 |
| Eric Gagne | 10.0 | 9.00 | 0 | 11 | X | -1.06 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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