| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.84 | LF-DH |
| Kevin Youkilis | 548 | 75 | 71 | 0.289 | 0.391 | 1.84 | 1B-3B |
| David Ortiz | 546 | 95 | 89 | 0.319 | 0.429 | 5.88 | DH |
| Mike Lowell | 533 | 60 | 93 | 0.323 | 0.377 | 2.95 | 3B |
| Julio Lugo | 526 | 55 | 62 | 0.237 | 0.291 | -0.66 | SS |
| Coco Crisp | 509 | 71 | 48 | 0.265 | 0.324 | -0.03 | CF |
| Dustin Pedroia | 463 | 65 | 42 | 0.315 | 0.384 | -0.16 | 2B |
| J.D. Drew | 454 | 66 | 47 | 0.257 | 0.357 | 0.69 | RF |
| Jason Varitek | 425 | 50 | 57 | 0.263 | 0.365 | 0.78 | CR |
| Alex Cora | 203 | 25 | 17 | 0.250 | 0.296 | -0.59 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.56 | LF |
| Eric Hinske | 163 | 20 | 16 | 0.197 | 0.319 | -0.23 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Bobby Kielty | 27 | 5 | 8 | 0.348 | 0.370 | 0.70 | X |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Kevin Cash | 16 | 2 | 1 | 0.182 | 0.438 | -0.08 | CR |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 176.3 | 3.83 | 27 | 0 | X | 2.52 |
| Josh Beckett | 166.7 | 3.29 | 25 | 0 | X | 4.46 |
| Tim Wakefield | 164.3 | 4.16 | 26 | 0 | X | 1.06 |
| Curt Schilling | 125.3 | 4.02 | 20 | 0 | X | 1.22 |
| Julian Tavarez | 122.7 | 4.84 | 21 | 7 | X | -1.15 |
| Hideki Okajima | 62.3 | 1.59 | 0 | 58 | X | 4.15 |
| Kyle Snyder | 48.0 | 3.75 | 0 | 41 | X | 0.77 |
| Jonathan Papelbon | 46.7 | 1.74 | 0 | 46 | X | 2.94 |
| Mike Timlin | 45.3 | 2.78 | 0 | 38 | X | 1.76 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.68 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.47 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.96 |
| Javier Lopez | 33.0 | 2.73 | 0 | 48 | X | 1.32 |
| Manny Delcarmen | 31.3 | 2.59 | 0 | 31 | X | 1.36 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 10.0 | 9.00 | 0 | 11 | X | -1.06 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
_