| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 548 | 80 | 85 | 0.292 | 0.385 | 3.85 | LF-DH |
| Kevin Youkilis | 540 | 74 | 69 | 0.290 | 0.387 | 1.74 | 1B-3B |
| David Ortiz | 538 | 94 | 88 | 0.322 | 0.433 | 5.88 | DH |
| Mike Lowell | 525 | 59 | 93 | 0.324 | 0.379 | 3.05 | 3B |
| Julio Lugo | 521 | 55 | 62 | 0.239 | 0.292 | -0.53 | SS |
| Coco Crisp | 501 | 71 | 48 | 0.270 | 0.329 | 0.18 | CF |
| Dustin Pedroia | 454 | 65 | 42 | 0.318 | 0.388 | 0.07 | 2B |
| J.D. Drew | 446 | 66 | 47 | 0.259 | 0.359 | 0.90 | RF |
| Jason Varitek | 418 | 50 | 57 | 0.265 | 0.359 | 0.96 | CR |
| Alex Cora | 200 | 25 | 17 | 0.254 | 0.300 | -0.51 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 156 | 20 | 16 | 0.206 | 0.327 | -0.06 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Bobby Kielty | 27 | 5 | 8 | 0.348 | 0.370 | 0.70 | X |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Kevin Cash | 16 | 2 | 1 | 0.182 | 0.438 | -0.08 | CR |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 176.3 | 3.83 | 27 | 0 | X | 2.50 |
| Tim Wakefield | 164.3 | 4.16 | 26 | 0 | X | 1.05 |
| Josh Beckett | 160.0 | 3.21 | 24 | 0 | X | 4.59 |
| Julian Tavarez | 122.7 | 4.84 | 21 | 7 | X | -1.17 |
| Curt Schilling | 118.3 | 4.11 | 19 | 0 | X | 0.91 |
| Hideki Okajima | 61.7 | 1.17 | 0 | 57 | X | 4.70 |
| Kyle Snyder | 47.7 | 3.78 | 0 | 40 | X | 0.73 |
| Jonathan Papelbon | 46.7 | 1.74 | 0 | 46 | X | 2.94 |
| Mike Timlin | 44.0 | 2.86 | 0 | 37 | X | 1.61 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.67 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.47 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.96 |
| Javier Lopez | 33.0 | 2.73 | 0 | 47 | X | 1.32 |
| Manny Delcarmen | 31.3 | 2.59 | 0 | 31 | X | 1.35 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 10.0 | 9.00 | 0 | 11 | X | -1.07 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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