| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 545 | 79 | 84 | 0.289 | 0.383 | 3.72 | LF-DH |
| Kevin Youkilis | 532 | 74 | 69 | 0.294 | 0.389 | 1.94 | 1B-3B |
| David Ortiz | 529 | 92 | 85 | 0.325 | 0.437 | 5.58 | DH |
| Mike Lowell | 516 | 59 | 92 | 0.324 | 0.380 | 3.17 | 3B |
| Julio Lugo | 512 | 52 | 61 | 0.240 | 0.293 | -0.72 | SS |
| Coco Crisp | 493 | 70 | 48 | 0.273 | 0.333 | 0.27 | CF |
| Dustin Pedroia | 445 | 64 | 40 | 0.321 | 0.391 | -0.02 | 2B |
| J.D. Drew | 437 | 64 | 46 | 0.261 | 0.359 | 0.81 | RF |
| Jason Varitek | 410 | 48 | 56 | 0.264 | 0.359 | 0.84 | CR |
| Alex Cora | 200 | 25 | 17 | 0.254 | 0.300 | -0.51 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 155 | 20 | 16 | 0.208 | 0.329 | -0.03 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Bobby Kielty | 23 | 3 | 6 | 0.316 | 0.348 | 0.38 | X |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Kevin Cash | 16 | 2 | 1 | 0.182 | 0.438 | -0.08 | CR |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 170.0 | 3.71 | 26 | 0 | X | 2.88 |
| Tim Wakefield | 164.3 | 4.16 | 26 | 0 | X | 1.03 |
| Josh Beckett | 160.0 | 3.21 | 24 | 0 | X | 4.57 |
| Curt Schilling | 118.3 | 4.11 | 19 | 0 | X | 0.89 |
| Julian Tavarez | 116.7 | 5.01 | 20 | 7 | X | -1.59 |
| Hideki Okajima | 61.7 | 1.17 | 0 | 57 | X | 4.70 |
| Kyle Snyder | 47.7 | 3.78 | 0 | 40 | X | 0.73 |
| Jonathan Papelbon | 45.7 | 1.77 | 0 | 45 | X | 2.83 |
| Mike Timlin | 44.0 | 2.86 | 0 | 37 | X | 1.61 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.67 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.47 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.96 |
| Javier Lopez | 32.7 | 2.76 | 0 | 46 | X | 1.28 |
| Manny Delcarmen | 29.0 | 2.79 | 0 | 29 | X | 1.11 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 9.0 | 10.00 | 0 | 10 | X | -1.17 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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