| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 540 | 77 | 84 | 0.291 | 0.383 | 3.60 | LF-DH |
| Kevin Youkilis | 526 | 73 | 67 | 0.292 | 0.388 | 1.74 | 1B-3B |
| David Ortiz | 524 | 90 | 83 | 0.324 | 0.437 | 5.26 | DH |
| Julio Lugo | 512 | 52 | 61 | 0.240 | 0.293 | -0.75 | SS |
| Mike Lowell | 510 | 57 | 90 | 0.319 | 0.376 | 2.87 | 3B |
| Coco Crisp | 487 | 69 | 47 | 0.271 | 0.329 | 0.18 | CF |
| Dustin Pedroia | 439 | 62 | 38 | 0.320 | 0.390 | -0.31 | 2B |
| J.D. Drew | 436 | 64 | 46 | 0.262 | 0.360 | 0.81 | RF |
| Jason Varitek | 410 | 48 | 56 | 0.264 | 0.359 | 0.82 | CR |
| Alex Cora | 194 | 24 | 17 | 0.262 | 0.304 | -0.47 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.56 | LF |
| Eric Hinske | 154 | 19 | 16 | 0.208 | 0.325 | -0.12 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.26 | CR |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Bobby Kielty | 17 | 2 | 2 | 0.214 | 0.235 | 0.00 | X |
| Kevin Cash | 11 | 1 | 1 | 0.222 | 0.364 | -0.06 | CR |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 170.0 | 3.71 | 26 | 0 | X | 2.87 |
| Josh Beckett | 160.0 | 3.21 | 24 | 0 | X | 4.56 |
| Tim Wakefield | 157.3 | 4.35 | 25 | 0 | X | 0.30 |
| Curt Schilling | 118.3 | 4.11 | 19 | 0 | X | 0.89 |
| Julian Tavarez | 116.7 | 5.01 | 20 | 7 | X | -1.59 |
| Hideki Okajima | 61.7 | 1.17 | 0 | 57 | X | 4.69 |
| Kyle Snyder | 46.7 | 3.47 | 0 | 39 | X | 1.04 |
| Jonathan Papelbon | 45.7 | 1.77 | 0 | 45 | X | 2.83 |
| Mike Timlin | 44.0 | 2.86 | 0 | 37 | X | 1.61 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.67 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.48 |
| Jon Lester | 33.3 | 5.67 | 6 | 0 | X | -0.97 |
| Javier Lopez | 31.7 | 2.84 | 0 | 45 | X | 1.17 |
| Manny Delcarmen | 29.0 | 2.79 | 0 | 29 | X | 1.11 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.67 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.60 |
| Eric Gagne | 9.0 | 10.00 | 0 | 10 | X | -1.17 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
_