| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 526 | 72 | 83 | 0.290 | 0.382 | 3.35 | LF-DH |
| Kevin Youkilis | 509 | 71 | 63 | 0.290 | 0.389 | 1.56 | 1B-3B |
| David Ortiz | 504 | 83 | 79 | 0.316 | 0.427 | 4.62 | DH |
| Julio Lugo | 493 | 52 | 58 | 0.239 | 0.294 | -0.57 | SS |
| Mike Lowell | 491 | 52 | 85 | 0.314 | 0.371 | 2.32 | 3B |
| Coco Crisp | 469 | 67 | 44 | 0.273 | 0.333 | 0.13 | CF |
| Dustin Pedroia | 427 | 59 | 38 | 0.325 | 0.393 | -0.31 | 2B |
| J.D. Drew | 424 | 62 | 46 | 0.262 | 0.361 | 0.92 | RF |
| Jason Varitek | 396 | 46 | 51 | 0.265 | 0.359 | 0.45 | CR |
| Alex Cora | 186 | 23 | 17 | 0.262 | 0.306 | -0.37 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 148 | 19 | 15 | 0.198 | 0.311 | -0.07 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| Bobby Kielty | 8 | 1 | 0 | 0.250 | 0.250 | -0.09 | X |
| Kevin Cash | 7 | 1 | 0 | 0.000 | 0.143 | -0.07 | CR |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 164.0 | 3.73 | 25 | 0 | X | 2.59 |
| Tim Wakefield | 157.3 | 4.35 | 25 | 0 | X | 0.23 |
| Josh Beckett | 154.3 | 3.15 | 23 | 0 | X | 4.54 |
| Julian Tavarez | 116.7 | 5.01 | 20 | 7 | X | -1.65 |
| Curt Schilling | 112.3 | 4.25 | 18 | 0 | X | 0.43 |
| Hideki Okajima | 59.7 | 1.21 | 0 | 55 | X | 4.46 |
| Kyle Snyder | 45.7 | 3.55 | 0 | 38 | X | 0.92 |
| Jonathan Papelbon | 44.3 | 1.83 | 0 | 44 | X | 2.67 |
| Mike Timlin | 41.0 | 3.07 | 0 | 35 | X | 1.28 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.65 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.49 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.12 |
| Jon Lester | 28.0 | 5.14 | 5 | 0 | X | -0.48 |
| Manny Delcarmen | 26.7 | 3.04 | 0 | 27 | X | 0.85 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.59 |
| Eric Gagne | 7.0 | 12.86 | 0 | 8 | X | -1.38 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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