| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 513 | 71 | 79 | 0.292 | 0.384 | 3.15 | LF-DH |
| Kevin Youkilis | 495 | 70 | 63 | 0.294 | 0.394 | 1.81 | 1B-3B |
| David Ortiz | 495 | 80 | 75 | 0.314 | 0.424 | 4.12 | DH |
| Mike Lowell | 481 | 51 | 81 | 0.310 | 0.362 | 2.05 | 3B |
| Julio Lugo | 480 | 51 | 56 | 0.238 | 0.296 | -0.55 | SS |
| Coco Crisp | 456 | 65 | 44 | 0.273 | 0.333 | 0.25 | CF |
| Dustin Pedroia | 418 | 57 | 37 | 0.324 | 0.392 | -0.40 | 2B |
| J.D. Drew | 414 | 61 | 46 | 0.266 | 0.365 | 1.07 | RF |
| Jason Varitek | 390 | 46 | 50 | 0.263 | 0.359 | 0.50 | CR |
| Alex Cora | 182 | 21 | 17 | 0.255 | 0.297 | -0.48 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 145 | 18 | 15 | 0.194 | 0.303 | -0.10 | 1B-LF-RF |
| Doug Mirabelli | 117 | 9 | 16 | 0.212 | 0.291 | -0.25 | CR |
| Jacoby Ellsbury | 22 | 4 | 1 | 0.316 | 0.409 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 164.0 | 3.73 | 25 | 0 | X | 2.58 |
| Josh Beckett | 154.3 | 3.15 | 23 | 0 | X | 4.53 |
| Tim Wakefield | 150.3 | 4.55 | 24 | 0 | X | -0.50 |
| Julian Tavarez | 110.7 | 5.12 | 19 | 7 | X | -1.85 |
| Curt Schilling | 106.3 | 4.06 | 17 | 0 | X | 0.85 |
| Hideki Okajima | 58.7 | 1.23 | 0 | 54 | X | 4.35 |
| Kyle Snyder | 43.7 | 3.50 | 0 | 37 | X | 0.92 |
| Jonathan Papelbon | 43.3 | 1.87 | 0 | 43 | X | 2.57 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.65 |
| Mike Timlin | 39.0 | 3.23 | 0 | 33 | X | 1.07 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.49 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.12 |
| Jon Lester | 28.0 | 5.14 | 5 | 0 | X | -0.48 |
| Manny Delcarmen | 25.7 | 3.16 | 0 | 26 | X | 0.75 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.59 |
| Clay Buchholz | 6.0 | 4.50 | 1 | 0 | X | -0.01 |
| Eric Gagne | 6.0 | 15.00 | 0 | 7 | X | -1.48 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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