| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 504 | 70 | 78 | 0.290 | 0.381 | 3.15 | LF-DH |
| Kevin Youkilis | 489 | 69 | 63 | 0.295 | 0.395 | 1.84 | 1B-3B |
| David Ortiz | 486 | 77 | 71 | 0.311 | 0.424 | 3.59 | DH |
| Julio Lugo | 476 | 50 | 56 | 0.238 | 0.294 | -0.57 | SS |
| Mike Lowell | 473 | 50 | 79 | 0.313 | 0.366 | 1.91 | 3B |
| Coco Crisp | 452 | 65 | 44 | 0.274 | 0.334 | 0.33 | CF |
| Dustin Pedroia | 409 | 54 | 36 | 0.324 | 0.394 | -0.61 | 2B |
| J.D. Drew | 405 | 60 | 45 | 0.258 | 0.360 | 1.07 | RF |
| Jason Varitek | 383 | 46 | 50 | 0.269 | 0.366 | 0.66 | CR |
| Alex Cora | 178 | 21 | 16 | 0.255 | 0.298 | -0.49 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 142 | 18 | 15 | 0.198 | 0.310 | -0.03 | 1B-LF-RF |
| Doug Mirabelli | 116 | 8 | 15 | 0.204 | 0.284 | -0.44 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 164.0 | 3.73 | 25 | 0 | X | 2.61 |
| Tim Wakefield | 150.3 | 4.55 | 24 | 0 | X | -0.47 |
| Josh Beckett | 147.3 | 3.24 | 22 | 0 | X | 4.05 |
| Julian Tavarez | 110.7 | 5.12 | 19 | 7 | X | -1.83 |
| Curt Schilling | 106.3 | 4.06 | 17 | 0 | X | 0.87 |
| Hideki Okajima | 57.0 | 1.26 | 0 | 53 | X | 4.19 |
| Kyle Snyder | 43.7 | 3.50 | 0 | 37 | X | 0.93 |
| Jonathan Papelbon | 42.0 | 1.93 | 0 | 42 | X | 2.44 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.65 |
| Mike Timlin | 39.0 | 3.23 | 0 | 33 | X | 1.08 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.49 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.13 |
| Jon Lester | 28.0 | 5.14 | 5 | 0 | X | -0.48 |
| Manny Delcarmen | 24.7 | 2.55 | 0 | 25 | X | 1.07 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.59 |
| Eric Gagne | 5.0 | 12.60 | 0 | 6 | X | -0.95 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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