| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 499 | 70 | 77 | 0.291 | 0.383 | 3.18 | LF-DH |
| Kevin Youkilis | 484 | 69 | 63 | 0.299 | 0.399 | 1.97 | 1B-3B |
| David Ortiz | 481 | 76 | 71 | 0.313 | 0.424 | 3.62 | DH |
| Julio Lugo | 472 | 50 | 54 | 0.235 | 0.292 | -0.67 | SS |
| Mike Lowell | 469 | 49 | 79 | 0.311 | 0.362 | 1.92 | 3B |
| Coco Crisp | 448 | 63 | 44 | 0.273 | 0.333 | 0.23 | CF |
| Dustin Pedroia | 404 | 54 | 36 | 0.328 | 0.396 | -0.47 | 2B |
| J.D. Drew | 401 | 60 | 45 | 0.261 | 0.364 | 1.17 | RF |
| Jason Varitek | 379 | 45 | 48 | 0.266 | 0.364 | 0.46 | CR |
| Alex Cora | 178 | 21 | 16 | 0.255 | 0.298 | -0.49 | 2B-SS |
| Wily Mo Pena | 172 | 18 | 17 | 0.218 | 0.291 | -0.55 | LF |
| Eric Hinske | 142 | 18 | 15 | 0.198 | 0.310 | -0.02 | 1B-LF-RF |
| Doug Mirabelli | 116 | 8 | 15 | 0.204 | 0.284 | -0.43 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 158.0 | 3.53 | 24 | 0 | X | 3.24 |
| Tim Wakefield | 150.3 | 4.55 | 24 | 0 | X | -0.49 |
| Josh Beckett | 147.3 | 3.24 | 22 | 0 | X | 4.03 |
| Julian Tavarez | 109.0 | 5.20 | 19 | 6 | X | -2.02 |
| Curt Schilling | 106.3 | 4.06 | 17 | 0 | X | 0.86 |
| Hideki Okajima | 57.0 | 1.26 | 0 | 53 | X | 4.18 |
| Kyle Snyder | 43.7 | 3.50 | 0 | 37 | X | 0.92 |
| Jonathan Papelbon | 42.0 | 1.93 | 0 | 42 | X | 2.43 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.65 |
| Mike Timlin | 37.7 | 3.35 | 0 | 32 | X | 0.94 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.49 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.12 |
| Jon Lester | 28.0 | 5.14 | 5 | 0 | X | -0.48 |
| Manny Delcarmen | 24.7 | 2.55 | 0 | 25 | X | 1.07 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.59 |
| Eric Gagne | 5.0 | 12.60 | 0 | 6 | X | -0.96 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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