| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 486 | 69 | 75 | 0.292 | 0.385 | 3.20 | LF-DH |
| Kevin Youkilis | 471 | 68 | 63 | 0.302 | 0.401 | 2.20 | 1B-3B |
| David Ortiz | 468 | 75 | 70 | 0.317 | 0.427 | 3.75 | DH |
| Julio Lugo | 460 | 49 | 52 | 0.232 | 0.291 | -0.68 | SS |
| Mike Lowell | 456 | 48 | 77 | 0.308 | 0.362 | 1.94 | 3B |
| Coco Crisp | 444 | 63 | 43 | 0.273 | 0.333 | 0.24 | CF |
| Dustin Pedroia | 395 | 54 | 36 | 0.330 | 0.400 | -0.24 | 2B |
| J.D. Drew | 391 | 60 | 45 | 0.259 | 0.363 | 1.43 | RF |
| Jason Varitek | 371 | 43 | 48 | 0.262 | 0.358 | 0.45 | CR |
| Alex Cora | 174 | 21 | 16 | 0.255 | 0.299 | -0.38 | 2B-SS |
| Wily Mo Pena | 170 | 18 | 17 | 0.221 | 0.294 | -0.49 | LF |
| Eric Hinske | 135 | 18 | 15 | 0.207 | 0.311 | 0.15 | 1B-LF-RF |
| Doug Mirabelli | 112 | 7 | 15 | 0.210 | 0.286 | -0.44 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 8 | 1 | 0 | 0.143 | 0.250 | -0.09 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 158.0 | 3.53 | 24 | 0 | X | 3.24 |
| Josh Beckett | 147.3 | 3.24 | 22 | 0 | X | 4.03 |
| Tim Wakefield | 142.3 | 4.81 | 23 | 0 | X | -1.31 |
| Julian Tavarez | 109.0 | 5.20 | 19 | 6 | X | -2.01 |
| Curt Schilling | 100.3 | 4.31 | 16 | 0 | X | 0.24 |
| Hideki Okajima | 56.7 | 1.11 | 0 | 52 | X | 4.36 |
| Kyle Snyder | 43.3 | 2.91 | 0 | 36 | X | 1.52 |
| Jonathan Papelbon | 41.0 | 1.98 | 0 | 41 | X | 2.33 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.65 |
| Mike Timlin | 36.3 | 3.47 | 0 | 30 | X | 0.80 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.49 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.12 |
| Manny Delcarmen | 23.0 | 2.74 | 0 | 23 | X | 0.90 |
| Jon Lester | 21.0 | 6.43 | 4 | 0 | X | -0.99 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.66 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.59 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
| Eric Gagne | 3.3 | 16.20 | 0 | 4 | X | -0.92 |
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