| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 472 | 67 | 72 | 0.297 | 0.390 | 3.03 | LF-DH |
| David Ortiz | 459 | 75 | 68 | 0.319 | 0.431 | 3.77 | DH |
| Kevin Youkilis | 457 | 67 | 61 | 0.306 | 0.400 | 2.24 | 1B-3B |
| Julio Lugo | 446 | 47 | 48 | 0.224 | 0.285 | -0.96 | SS |
| Mike Lowell | 442 | 47 | 75 | 0.304 | 0.355 | 1.98 | 3B |
| Coco Crisp | 433 | 60 | 43 | 0.277 | 0.335 | 0.20 | CF |
| Dustin Pedroia | 381 | 50 | 34 | 0.322 | 0.394 | -0.52 | 2B |
| J.D. Drew | 380 | 58 | 42 | 0.251 | 0.355 | 1.19 | RF |
| Jason Varitek | 357 | 40 | 48 | 0.266 | 0.361 | 0.49 | CR |
| Alex Cora | 174 | 21 | 16 | 0.255 | 0.299 | -0.38 | 2B-SS |
| Wily Mo Pena | 164 | 17 | 16 | 0.223 | 0.299 | -0.55 | LF |
| Eric Hinske | 135 | 18 | 15 | 0.207 | 0.311 | 0.16 | 1B-LF-RF |
| Doug Mirabelli | 112 | 7 | 15 | 0.210 | 0.286 | -0.43 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 151.0 | 3.64 | 23 | 0 | X | 2.70 |
| Tim Wakefield | 142.3 | 4.81 | 23 | 0 | X | -1.34 |
| Josh Beckett | 138.7 | 3.31 | 21 | 0 | X | 3.53 |
| Julian Tavarez | 108.0 | 5.17 | 19 | 5 | X | -1.93 |
| Curt Schilling | 100.3 | 4.31 | 16 | 0 | X | 0.23 |
| Hideki Okajima | 54.0 | 1.00 | 0 | 50 | X | 4.29 |
| Kyle Snyder | 43.3 | 2.91 | 0 | 36 | X | 1.51 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.64 |
| Jonathan Papelbon | 39.7 | 2.04 | 0 | 39 | X | 2.18 |
| Mike Timlin | 35.0 | 3.60 | 0 | 29 | X | 0.66 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.50 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.12 |
| Manny Delcarmen | 23.0 | 2.74 | 0 | 22 | X | 0.89 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.65 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.58 |
| Jon Lester | 17.7 | 5.09 | 3 | 0 | X | -0.29 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
| Eric Gagne | 2.0 | 9.00 | 0 | 2 | X | -0.21 |
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