| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 468 | 67 | 71 | 0.297 | 0.391 | 3.04 | LF-DH |
| David Ortiz | 455 | 75 | 68 | 0.323 | 0.435 | 3.88 | DH |
| Kevin Youkilis | 453 | 67 | 60 | 0.304 | 0.400 | 2.25 | 1B-3B |
| Julio Lugo | 442 | 47 | 48 | 0.227 | 0.287 | -0.84 | SS |
| Mike Lowell | 438 | 47 | 75 | 0.305 | 0.356 | 2.09 | 3B |
| Coco Crisp | 429 | 60 | 43 | 0.277 | 0.336 | 0.32 | CF |
| J.D. Drew | 378 | 58 | 42 | 0.252 | 0.357 | 1.25 | RF |
| Dustin Pedroia | 377 | 48 | 34 | 0.320 | 0.393 | -0.62 | 2B |
| Jason Varitek | 357 | 40 | 48 | 0.266 | 0.361 | 0.50 | CR |
| Alex Cora | 174 | 21 | 16 | 0.255 | 0.299 | -0.37 | 2B-SS |
| Wily Mo Pena | 162 | 16 | 16 | 0.218 | 0.290 | -0.60 | LF |
| Eric Hinske | 135 | 18 | 15 | 0.207 | 0.311 | 0.16 | 1B-LF-RF |
| Doug Mirabelli | 108 | 6 | 13 | 0.208 | 0.287 | -0.65 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| Brandon Moss | 3 | 0 | 0 | 0.000 | 0.333 | -0.07 | LF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 151.0 | 3.64 | 23 | 0 | X | 2.68 |
| Josh Beckett | 138.7 | 3.31 | 21 | 0 | X | 3.51 |
| Tim Wakefield | 138.3 | 4.55 | 22 | 0 | X | -0.51 |
| Julian Tavarez | 107.0 | 5.05 | 19 | 4 | X | -1.63 |
| Curt Schilling | 100.3 | 4.31 | 16 | 0 | X | 0.21 |
| Hideki Okajima | 54.0 | 1.00 | 0 | 50 | X | 4.28 |
| Kyle Snyder | 41.3 | 2.83 | 0 | 35 | X | 1.51 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.63 |
| Jonathan Papelbon | 39.7 | 2.04 | 0 | 39 | X | 2.18 |
| Mike Timlin | 35.0 | 3.60 | 0 | 29 | X | 0.65 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.50 |
| Javier Lopez | 31.3 | 2.87 | 0 | 44 | X | 1.11 |
| Manny Delcarmen | 22.0 | 2.86 | 0 | 21 | X | 0.79 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.65 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.58 |
| Jon Lester | 17.7 | 5.09 | 3 | 0 | X | -0.29 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
| Eric Gagne | 2.0 | 9.00 | 0 | 2 | X | -0.21 |
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