| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 435 | 63 | 66 | 0.303 | 0.400 | 2.92 | LF-DH |
| David Ortiz | 418 | 66 | 61 | 0.320 | 0.433 | 3.13 | DH |
| Kevin Youkilis | 415 | 63 | 54 | 0.305 | 0.402 | 2.15 | 1B-3B |
| Julio Lugo | 410 | 45 | 48 | 0.224 | 0.288 | -0.25 | SS |
| Mike Lowell | 404 | 47 | 73 | 0.311 | 0.361 | 2.73 | 3B |
| Coco Crisp | 394 | 56 | 42 | 0.281 | 0.330 | 0.67 | CF |
| J.D. Drew | 361 | 57 | 41 | 0.248 | 0.355 | 1.47 | RF |
| Dustin Pedroia | 342 | 43 | 30 | 0.315 | 0.386 | -0.69 | 2B |
| Jason Varitek | 331 | 40 | 44 | 0.271 | 0.363 | 0.74 | CR |
| Alex Cora | 165 | 19 | 15 | 0.253 | 0.297 | -0.46 | 2B-SS |
| Wily Mo Pena | 150 | 15 | 16 | 0.219 | 0.287 | -0.41 | LF |
| Eric Hinske | 129 | 16 | 14 | 0.205 | 0.302 | 0.00 | 1B-LF-RF |
| Doug Mirabelli | 101 | 4 | 11 | 0.185 | 0.257 | -0.89 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 137.7 | 3.79 | 21 | 0 | X | 1.84 |
| Tim Wakefield | 131.3 | 4.59 | 21 | 0 | X | -0.69 |
| Josh Beckett | 124.0 | 3.27 | 19 | 0 | X | 3.18 |
| Julian Tavarez | 100.0 | 5.13 | 18 | 2 | X | -1.79 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.37 |
| Hideki Okajima | 51.7 | 0.87 | 0 | 47 | X | 4.21 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.61 |
| Kyle Snyder | 38.7 | 2.79 | 0 | 33 | X | 1.42 |
| Jonathan Papelbon | 37.7 | 2.15 | 0 | 37 | X | 1.95 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.53 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.81 |
| Javier Lopez | 29.3 | 3.07 | 0 | 41 | X | 0.89 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.63 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 19.3 | 1.40 | 0 | 17 | X | 1.34 |
| Jon Lester | 12.7 | 4.26 | 2 | 0 | X | 0.03 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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