| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 428 | 63 | 63 | 0.306 | 0.404 | 2.72 | LF-DH |
| David Ortiz | 411 | 64 | 60 | 0.320 | 0.433 | 2.93 | DH |
| Kevin Youkilis | 408 | 61 | 51 | 0.306 | 0.402 | 1.74 | 1B-3B |
| Julio Lugo | 403 | 43 | 46 | 0.222 | 0.283 | -0.55 | SS |
| Mike Lowell | 398 | 46 | 73 | 0.306 | 0.357 | 2.72 | 3B |
| Coco Crisp | 388 | 55 | 41 | 0.282 | 0.330 | 0.55 | CF |
| J.D. Drew | 354 | 56 | 40 | 0.247 | 0.356 | 1.39 | RF |
| Dustin Pedroia | 342 | 43 | 30 | 0.315 | 0.386 | -0.73 | 2B |
| Jason Varitek | 325 | 38 | 43 | 0.268 | 0.357 | 0.53 | CR |
| Alex Cora | 159 | 18 | 15 | 0.262 | 0.302 | -0.44 | 2B-SS |
| Wily Mo Pena | 150 | 15 | 16 | 0.219 | 0.287 | -0.43 | LF |
| Eric Hinske | 129 | 16 | 14 | 0.205 | 0.302 | -0.02 | 1B-LF-RF |
| Doug Mirabelli | 101 | 4 | 11 | 0.185 | 0.257 | -0.90 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 137.7 | 3.79 | 21 | 0 | X | 1.90 |
| Tim Wakefield | 131.3 | 4.59 | 21 | 0 | X | -0.64 |
| Josh Beckett | 124.0 | 3.27 | 19 | 0 | X | 3.23 |
| Julian Tavarez | 99.7 | 5.15 | 18 | 1 | X | -1.78 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.41 |
| Hideki Okajima | 50.7 | 0.89 | 0 | 46 | X | 4.13 |
| Kason Gabbard | 41.0 | 3.73 | 7 | 0 | X | 0.62 |
| Kyle Snyder | 36.7 | 2.95 | 0 | 32 | X | 1.23 |
| Jonathan Papelbon | 36.7 | 1.72 | 0 | 36 | X | 2.28 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.51 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.82 |
| Javier Lopez | 28.3 | 3.18 | 0 | 40 | X | 0.80 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 19.3 | 1.40 | 0 | 17 | X | 1.35 |
| Jon Lester | 6.0 | 3.00 | 1 | 0 | X | 0.19 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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