| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 419 | 58 | 59 | 0.298 | 0.399 | 2.01 | LF-DH |
| David Ortiz | 401 | 61 | 60 | 0.320 | 0.431 | 2.88 | DH |
| Kevin Youkilis | 398 | 58 | 48 | 0.312 | 0.407 | 1.37 | 1B-3B |
| Julio Lugo | 392 | 42 | 46 | 0.225 | 0.286 | -0.37 | SS |
| Mike Lowell | 389 | 46 | 71 | 0.304 | 0.355 | 2.75 | 3B |
| Coco Crisp | 379 | 52 | 38 | 0.281 | 0.330 | 0.16 | CF |
| J.D. Drew | 350 | 55 | 39 | 0.247 | 0.354 | 1.29 | RF |
| Dustin Pedroia | 336 | 42 | 30 | 0.318 | 0.390 | -0.68 | 2B |
| Jason Varitek | 320 | 37 | 41 | 0.265 | 0.356 | 0.35 | CR |
| Alex Cora | 155 | 17 | 15 | 0.268 | 0.303 | -0.44 | 2B-SS |
| Wily Mo Pena | 145 | 13 | 12 | 0.197 | 0.269 | -0.93 | LF |
| Eric Hinske | 129 | 16 | 14 | 0.205 | 0.302 | -0.01 | 1B-LF-RF |
| Doug Mirabelli | 97 | 4 | 10 | 0.182 | 0.258 | -0.91 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 137.7 | 3.79 | 21 | 0 | X | 1.86 |
| Tim Wakefield | 125.3 | 4.74 | 20 | 0 | X | -1.07 |
| Josh Beckett | 124.0 | 3.27 | 19 | 0 | X | 3.20 |
| Julian Tavarez | 97.3 | 5.27 | 18 | 0 | X | -2.04 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.38 |
| Hideki Okajima | 49.7 | 0.91 | 0 | 45 | X | 4.02 |
| Jonathan Papelbon | 36.7 | 1.72 | 0 | 36 | X | 2.27 |
| Kason Gabbard | 36.3 | 2.97 | 6 | 0 | X | 1.19 |
| Kyle Snyder | 35.7 | 3.03 | 0 | 31 | X | 1.12 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.52 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.81 |
| Javier Lopez | 27.3 | 3.29 | 0 | 39 | X | 0.69 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 17.3 | 1.56 | 0 | 16 | X | 1.14 |
| Jon Lester | 6.0 | 3.00 | 1 | 0 | X | 0.19 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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