| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Manny Ramirez | 416 | 58 | 59 | 0.300 | 0.399 | 2.11 | LF-DH |
| David Ortiz | 397 | 61 | 60 | 0.321 | 0.433 | 3.00 | DH |
| Kevin Youkilis | 395 | 58 | 48 | 0.314 | 0.410 | 1.47 | 1B-3B |
| Julio Lugo | 392 | 42 | 46 | 0.225 | 0.286 | -0.34 | SS |
| Mike Lowell | 389 | 46 | 71 | 0.304 | 0.355 | 2.77 | 3B |
| Coco Crisp | 375 | 52 | 38 | 0.281 | 0.331 | 0.28 | CF |
| J.D. Drew | 347 | 55 | 39 | 0.249 | 0.357 | 1.39 | RF |
| Dustin Pedroia | 332 | 42 | 30 | 0.321 | 0.392 | -0.56 | 2B |
| Jason Varitek | 317 | 37 | 41 | 0.264 | 0.353 | 0.44 | CR |
| Alex Cora | 152 | 17 | 15 | 0.267 | 0.303 | -0.36 | 2B-SS |
| Wily Mo Pena | 145 | 13 | 12 | 0.197 | 0.269 | -0.92 | LF |
| Eric Hinske | 126 | 16 | 14 | 0.211 | 0.310 | 0.07 | 1B-LF-RF |
| Doug Mirabelli | 97 | 4 | 10 | 0.182 | 0.258 | -0.90 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 137.7 | 3.79 | 21 | 0 | X | 1.85 |
| Tim Wakefield | 125.3 | 4.74 | 20 | 0 | X | -1.09 |
| Josh Beckett | 116.0 | 3.41 | 18 | 0 | X | 2.58 |
| Julian Tavarez | 97.3 | 5.27 | 18 | 0 | X | -2.05 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.37 |
| Hideki Okajima | 49.7 | 0.91 | 0 | 45 | X | 4.01 |
| Jonathan Papelbon | 36.7 | 1.72 | 0 | 36 | X | 2.27 |
| Kason Gabbard | 36.3 | 2.97 | 6 | 0 | X | 1.18 |
| Kyle Snyder | 35.7 | 3.03 | 0 | 31 | X | 1.11 |
| Joel Pineiro | 34.0 | 5.03 | 0 | 31 | X | -0.53 |
| Mike Timlin | 32.7 | 3.31 | 0 | 27 | X | 0.81 |
| Javier Lopez | 27.3 | 3.29 | 0 | 39 | X | 0.68 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 17.3 | 1.56 | 0 | 16 | X | 1.14 |
| Jon Lester | 6.0 | 3.00 | 1 | 0 | X | 0.19 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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