| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 397 | 61 | 60 | 0.321 | 0.433 | 3.01 | DH |
| Manny Ramirez | 397 | 53 | 53 | 0.295 | 0.390 | 1.44 | LF-DH |
| Kevin Youkilis | 376 | 53 | 46 | 0.309 | 0.404 | 1.22 | 1B-3B |
| Julio Lugo | 374 | 41 | 46 | 0.224 | 0.283 | 0.00 | SS |
| Mike Lowell | 371 | 43 | 66 | 0.306 | 0.353 | 2.39 | 3B |
| Coco Crisp | 358 | 48 | 33 | 0.265 | 0.318 | -0.24 | CF |
| J.D. Drew | 329 | 52 | 36 | 0.255 | 0.362 | 1.21 | RF |
| Dustin Pedroia | 318 | 41 | 29 | 0.319 | 0.393 | -0.41 | 2B |
| Jason Varitek | 306 | 36 | 40 | 0.268 | 0.353 | 0.51 | CR |
| Alex Cora | 147 | 16 | 15 | 0.277 | 0.313 | -0.33 | 2B-SS |
| Wily Mo Pena | 140 | 13 | 12 | 0.205 | 0.279 | -0.79 | LF |
| Eric Hinske | 116 | 15 | 12 | 0.200 | 0.302 | 0.00 | 1B-LF-RF |
| Doug Mirabelli | 93 | 3 | 10 | 0.188 | 0.258 | -0.91 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 130.7 | 3.99 | 20 | 0 | X | 1.11 |
| Tim Wakefield | 119.0 | 4.69 | 19 | 0 | X | -0.92 |
| Josh Beckett | 116.0 | 3.41 | 18 | 0 | X | 2.56 |
| Julian Tavarez | 97.3 | 5.27 | 18 | 0 | X | -2.07 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.35 |
| Hideki Okajima | 47.3 | 0.95 | 0 | 43 | X | 3.76 |
| Kyle Snyder | 35.7 | 3.03 | 0 | 31 | X | 1.11 |
| Jonathan Papelbon | 34.7 | 1.82 | 0 | 34 | X | 2.06 |
| Joel Pineiro | 33.0 | 4.91 | 0 | 30 | X | -0.42 |
| Mike Timlin | 31.3 | 3.45 | 0 | 26 | X | 0.67 |
| Kason Gabbard | 29.3 | 3.38 | 5 | 0 | X | 0.67 |
| Javier Lopez | 26.0 | 3.46 | 0 | 37 | X | 0.54 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.63 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.56 |
| Manny Delcarmen | 15.7 | 1.15 | 0 | 14 | X | 1.17 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.37 |
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