| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 390 | 60 | 59 | 0.321 | 0.433 | 2.97 | DH |
| Manny Ramirez | 389 | 52 | 53 | 0.292 | 0.388 | 1.53 | LF-DH |
| Kevin Youkilis | 371 | 52 | 46 | 0.313 | 0.407 | 1.23 | 1B-3B |
| Julio Lugo | 366 | 38 | 41 | 0.217 | 0.279 | -0.64 | SS |
| Mike Lowell | 363 | 41 | 66 | 0.306 | 0.353 | 2.37 | 3B |
| Coco Crisp | 348 | 47 | 30 | 0.266 | 0.319 | -0.41 | CF |
| J.D. Drew | 325 | 51 | 35 | 0.252 | 0.360 | 1.10 | RF |
| Dustin Pedroia | 308 | 41 | 28 | 0.316 | 0.393 | -0.27 | 2B |
| Jason Varitek | 298 | 35 | 39 | 0.270 | 0.356 | 0.50 | CR |
| Alex Cora | 146 | 16 | 15 | 0.279 | 0.315 | -0.31 | 2B-SS |
| Wily Mo Pena | 136 | 13 | 12 | 0.210 | 0.279 | -0.70 | LF |
| Eric Hinske | 113 | 14 | 12 | 0.196 | 0.301 | -0.03 | 1B-LF-RF |
| Doug Mirabelli | 93 | 3 | 10 | 0.188 | 0.258 | -0.91 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 125.7 | 3.94 | 19 | 0 | X | 1.24 |
| Tim Wakefield | 119.0 | 4.69 | 19 | 0 | X | -0.90 |
| Josh Beckett | 110.0 | 3.35 | 17 | 0 | X | 2.59 |
| Julian Tavarez | 97.3 | 5.27 | 18 | 0 | X | -2.06 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.36 |
| Hideki Okajima | 45.3 | 0.79 | 0 | 41 | X | 3.78 |
| Jonathan Papelbon | 34.7 | 1.82 | 0 | 34 | X | 2.06 |
| Kyle Snyder | 34.7 | 3.12 | 0 | 30 | X | 1.01 |
| Joel Pineiro | 32.0 | 5.06 | 0 | 29 | X | -0.52 |
| Mike Timlin | 30.3 | 3.56 | 0 | 25 | X | 0.57 |
| Kason Gabbard | 29.3 | 3.38 | 5 | 0 | X | 0.68 |
| Javier Lopez | 25.0 | 3.60 | 0 | 36 | X | 0.45 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.63 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 14.7 | 1.23 | 0 | 13 | X | 1.07 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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