| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 385 | 60 | 59 | 0.320 | 0.434 | 3.09 | DH |
| Manny Ramirez | 384 | 50 | 52 | 0.289 | 0.385 | 1.33 | LF-DH |
| Kevin Youkilis | 367 | 51 | 46 | 0.316 | 0.409 | 1.22 | 1B-3B |
| Julio Lugo | 362 | 38 | 39 | 0.217 | 0.279 | -0.76 | SS |
| Mike Lowell | 359 | 41 | 66 | 0.307 | 0.354 | 2.46 | 3B |
| Coco Crisp | 344 | 46 | 30 | 0.265 | 0.317 | -0.43 | CF |
| J.D. Drew | 320 | 51 | 34 | 0.256 | 0.366 | 1.11 | RF |
| Dustin Pedroia | 303 | 41 | 28 | 0.311 | 0.389 | -0.16 | 2B |
| Jason Varitek | 294 | 34 | 38 | 0.275 | 0.361 | 0.38 | CR |
| Alex Cora | 146 | 16 | 15 | 0.279 | 0.315 | -0.31 | 2B-SS |
| Wily Mo Pena | 136 | 13 | 12 | 0.210 | 0.279 | -0.70 | LF |
| Eric Hinske | 113 | 14 | 12 | 0.196 | 0.301 | -0.03 | 1B-LF-RF |
| Doug Mirabelli | 93 | 3 | 10 | 0.188 | 0.258 | -0.91 | CR |
| Jacoby Ellsbury | 18 | 3 | 1 | 0.375 | 0.444 | -0.02 | LF-CF |
| Jeff Bailey | 9 | 1 | 1 | 0.111 | 0.111 | -0.01 | X |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 125.7 | 3.94 | 19 | 0 | X | 1.25 |
| Tim Wakefield | 119.0 | 4.69 | 19 | 0 | X | -0.90 |
| Josh Beckett | 110.0 | 3.35 | 17 | 0 | X | 2.60 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.37 |
| Julian Tavarez | 92.7 | 5.15 | 17 | 0 | X | -1.69 |
| Hideki Okajima | 45.3 | 0.79 | 0 | 41 | X | 3.78 |
| Kyle Snyder | 34.7 | 3.12 | 0 | 30 | X | 1.01 |
| Jonathan Papelbon | 33.7 | 1.87 | 0 | 33 | X | 1.96 |
| Joel Pineiro | 32.0 | 5.06 | 0 | 29 | X | -0.52 |
| Kason Gabbard | 29.3 | 3.38 | 5 | 0 | X | 0.68 |
| Mike Timlin | 28.0 | 3.86 | 0 | 24 | X | 0.33 |
| Javier Lopez | 25.0 | 3.60 | 0 | 36 | X | 0.45 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Manny Delcarmen | 13.7 | 1.32 | 0 | 12 | X | 0.97 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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