| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 343 | 50 | 44 | 0.329 | 0.420 | 1.49 | 1B-3B |
| Manny Ramirez | 343 | 43 | 43 | 0.285 | 0.385 | 0.65 | LF-DH |
| David Ortiz | 337 | 49 | 49 | 0.307 | 0.421 | 2.06 | DH |
| Julio Lugo | 321 | 32 | 35 | 0.193 | 0.259 | -0.80 | SS |
| Mike Lowell | 311 | 34 | 55 | 0.293 | 0.347 | 1.75 | 3B |
| Coco Crisp | 295 | 40 | 22 | 0.263 | 0.312 | -0.69 | CF |
| J.D. Drew | 283 | 45 | 33 | 0.257 | 0.371 | 1.28 | RF |
| Jason Varitek | 265 | 31 | 35 | 0.272 | 0.362 | 0.46 | CR |
| Dustin Pedroia | 259 | 34 | 25 | 0.320 | 0.398 | -0.13 | 2B |
| Alex Cora | 133 | 14 | 14 | 0.282 | 0.323 | -0.31 | 2B-SS |
| Wily Mo Pena | 122 | 13 | 12 | 0.216 | 0.287 | -0.35 | LF |
| Eric Hinske | 90 | 13 | 11 | 0.218 | 0.311 | 0.32 | 1B-LF-RF |
| Doug Mirabelli | 74 | 2 | 5 | 0.174 | 0.230 | -1.07 | CR |
| Jacoby Ellsbury | 12 | 2 | 0 | 0.300 | 0.417 | -0.08 | LF-CF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 114.7 | 3.53 | 17 | 0 | X | 2.21 |
| Tim Wakefield | 100.3 | 4.31 | 16 | 0 | X | 0.12 |
| Josh Beckett | 96.0 | 3.38 | 15 | 0 | X | 2.20 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.35 |
| Julian Tavarez | 84.0 | 4.39 | 15 | 0 | X | -0.07 |
| Hideki Okajima | 41.0 | 0.88 | 0 | 38 | X | 3.33 |
| Jonathan Papelbon | 31.0 | 1.74 | 0 | 30 | X | 1.89 |
| Joel Pineiro | 30.3 | 5.04 | 0 | 27 | X | -0.49 |
| Kyle Snyder | 30.0 | 2.40 | 0 | 26 | X | 1.37 |
| Javier Lopez | 20.7 | 3.05 | 0 | 30 | X | 0.63 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.63 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.56 |
| Mike Timlin | 19.3 | 5.59 | 0 | 19 | X | -0.55 |
| Kason Gabbard | 14.0 | 5.79 | 3 | 0 | X | -0.47 |
| Manny Delcarmen | 7.0 | 2.57 | 0 | 7 | X | 0.29 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.37 |
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