| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 339 | 48 | 44 | 0.329 | 0.419 | 1.40 | 1B-3B |
| Manny Ramirez | 334 | 41 | 42 | 0.285 | 0.383 | 0.57 | LF-DH |
| David Ortiz | 328 | 49 | 49 | 0.314 | 0.430 | 2.29 | DH |
| Julio Lugo | 313 | 32 | 33 | 0.189 | 0.252 | -0.81 | SS |
| Mike Lowell | 303 | 33 | 55 | 0.297 | 0.350 | 1.85 | 3B |
| Coco Crisp | 291 | 40 | 22 | 0.262 | 0.309 | -0.58 | CF |
| J.D. Drew | 278 | 44 | 33 | 0.260 | 0.367 | 1.31 | RF |
| Jason Varitek | 257 | 30 | 33 | 0.266 | 0.358 | 0.35 | CR |
| Dustin Pedroia | 250 | 33 | 23 | 0.323 | 0.400 | -0.21 | 2B |
| Alex Cora | 133 | 14 | 14 | 0.282 | 0.323 | -0.30 | 2B-SS |
| Wily Mo Pena | 118 | 13 | 12 | 0.224 | 0.297 | -0.25 | LF |
| Eric Hinske | 86 | 12 | 8 | 0.203 | 0.302 | 0.00 | 1B-LF-RF |
| Doug Mirabelli | 74 | 2 | 5 | 0.174 | 0.230 | -1.07 | CR |
| Jacoby Ellsbury | 8 | 0 | 0 | 0.125 | 0.125 | -0.20 | LF-CF |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 106.7 | 3.80 | 16 | 0 | X | 1.40 |
| Tim Wakefield | 100.3 | 4.31 | 16 | 0 | X | 0.12 |
| Josh Beckett | 96.0 | 3.38 | 15 | 0 | X | 2.20 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.35 |
| Julian Tavarez | 84.0 | 4.39 | 15 | 0 | X | -0.07 |
| Hideki Okajima | 40.0 | 0.90 | 0 | 37 | X | 3.23 |
| Joel Pineiro | 30.3 | 5.04 | 0 | 27 | X | -0.49 |
| Jonathan Papelbon | 30.0 | 1.50 | 0 | 29 | X | 2.00 |
| Kyle Snyder | 29.0 | 2.48 | 0 | 25 | X | 1.27 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.63 |
| Javier Lopez | 20.3 | 3.10 | 0 | 29 | X | 0.60 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.56 |
| Mike Timlin | 18.3 | 5.89 | 0 | 18 | X | -0.66 |
| Kason Gabbard | 8.3 | 6.48 | 2 | 0 | X | -0.41 |
| Manny Delcarmen | 7.0 | 2.57 | 0 | 7 | X | 0.29 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.37 |
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