| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 325 | 45 | 41 | 0.330 | 0.415 | 1.09 | 1B-3B |
| Manny Ramirez | 321 | 40 | 42 | 0.289 | 0.386 | 0.77 | LF-DH |
| David Ortiz | 314 | 49 | 48 | 0.319 | 0.433 | 2.51 | DH |
| Julio Lugo | 313 | 32 | 33 | 0.189 | 0.252 | -0.82 | SS |
| Mike Lowell | 295 | 33 | 54 | 0.293 | 0.349 | 1.93 | 3B |
| Coco Crisp | 291 | 40 | 22 | 0.262 | 0.309 | -0.60 | CF |
| J.D. Drew | 266 | 44 | 33 | 0.251 | 0.353 | 1.59 | RF |
| Jason Varitek | 248 | 30 | 33 | 0.266 | 0.359 | 0.56 | CR |
| Dustin Pedroia | 235 | 32 | 23 | 0.322 | 0.396 | 0.03 | 2B |
| Alex Cora | 121 | 12 | 14 | 0.283 | 0.322 | -0.23 | 2B-SS |
| Wily Mo Pena | 114 | 13 | 11 | 0.223 | 0.298 | -0.27 | LF |
| Eric Hinske | 82 | 12 | 8 | 0.214 | 0.317 | 0.10 | 1B-LF-RF |
| Doug Mirabelli | 71 | 2 | 5 | 0.182 | 0.239 | -1.00 | CR |
| David Murphy | 2 | 1 | 0 | 0.500 | 0.500 | 0.06 | LF-RF-CF |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 106.7 | 3.80 | 16 | 0 | X | 1.43 |
| Curt Schilling | 94.3 | 4.20 | 15 | 0 | X | 0.38 |
| Tim Wakefield | 93.7 | 4.52 | 15 | 0 | X | -0.32 |
| Josh Beckett | 91.0 | 3.07 | 14 | 0 | X | 2.77 |
| Julian Tavarez | 78.3 | 4.60 | 14 | 0 | X | -0.41 |
| Hideki Okajima | 38.0 | 0.95 | 0 | 35 | X | 3.03 |
| Joel Pineiro | 30.3 | 5.04 | 0 | 27 | X | -0.48 |
| Jonathan Papelbon | 29.0 | 1.55 | 0 | 28 | X | 1.91 |
| Kyle Snyder | 27.0 | 2.67 | 0 | 24 | X | 1.07 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.64 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.57 |
| Javier Lopez | 18.7 | 3.37 | 0 | 27 | X | 0.43 |
| Mike Timlin | 17.3 | 6.23 | 0 | 17 | X | -0.75 |
| Kason Gabbard | 8.3 | 6.48 | 2 | 0 | X | -0.41 |
| Manny Delcarmen | 5.0 | 3.60 | 0 | 5 | X | 0.09 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.36 |
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