| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 267 | 43 | 32 | 0.336 | 0.423 | 1.44 | 1B-3B |
| Julio Lugo | 267 | 28 | 33 | 0.213 | 0.270 | -0.03 | SS |
| Manny Ramirez | 262 | 34 | 33 | 0.291 | 0.389 | 0.72 | LF-DH |
| David Ortiz | 257 | 43 | 42 | 0.330 | 0.444 | 2.73 | DH |
| Mike Lowell | 242 | 30 | 47 | 0.312 | 0.372 | 2.25 | 3B |
| Coco Crisp | 232 | 30 | 16 | 0.224 | 0.276 | -0.76 | CF |
| J.D. Drew | 207 | 33 | 25 | 0.244 | 0.353 | 1.10 | RF |
| Jason Varitek | 199 | 27 | 31 | 0.267 | 0.357 | 1.29 | CR |
| Dustin Pedroia | 175 | 22 | 16 | 0.316 | 0.394 | -0.23 | 2B |
| Alex Cora | 98 | 9 | 13 | 0.287 | 0.316 | -0.05 | 2B-SS |
| Wily Mo Pena | 93 | 12 | 10 | 0.241 | 0.323 | 0.07 | LF |
| Eric Hinske | 73 | 10 | 5 | 0.177 | 0.288 | -0.18 | 1B-LF-RF |
| Doug Mirabelli | 57 | 2 | 4 | 0.204 | 0.246 | -0.74 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 85.7 | 4.52 | 13 | 0 | X | -0.42 |
| Curt Schilling | 85.0 | 3.49 | 13 | 0 | X | 1.61 |
| Tim Wakefield | 74.7 | 4.22 | 12 | 0 | X | 0.15 |
| Josh Beckett | 72.0 | 2.88 | 11 | 0 | X | 2.41 |
| Julian Tavarez | 60.0 | 5.25 | 11 | 0 | X | -1.32 |
| Hideki Okajima | 31.7 | 1.14 | 0 | 28 | X | 2.34 |
| Joel Pineiro | 24.3 | 4.81 | 0 | 22 | X | -0.28 |
| Jonathan Papelbon | 22.3 | 2.01 | 0 | 22 | X | 1.19 |
| Brendan Donnelly | 20.7 | 3.05 | 0 | 27 | X | 0.61 |
| J.C. Romero | 20.0 | 3.15 | 0 | 23 | X | 0.54 |
| Kyle Snyder | 20.0 | 2.25 | 0 | 18 | X | 0.96 |
| Javier Lopez | 14.0 | 3.21 | 0 | 20 | X | 0.36 |
| Mike Timlin | 9.7 | 5.59 | 0 | 10 | X | -0.29 |
| Kason Gabbard | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.37 |
| Manny Delcarmen | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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