| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| Kevin Youkilis | 230 | 41 | 30 | 0.353 | 0.430 | 1.91 | 1B-3B |
| Julio Lugo | 228 | 26 | 30 | 0.224 | 0.281 | 0.39 | SS |
| Manny Ramirez | 227 | 28 | 32 | 0.283 | 0.366 | 0.83 | LF-DH |
| David Ortiz | 221 | 35 | 39 | 0.324 | 0.439 | 2.44 | DH |
| Mike Lowell | 209 | 28 | 41 | 0.328 | 0.388 | 2.21 | 3B |
| Coco Crisp | 199 | 29 | 15 | 0.229 | 0.286 | -0.18 | CF |
| J.D. Drew | 188 | 29 | 18 | 0.222 | 0.340 | 0.40 | RF |
| Jason Varitek | 166 | 22 | 26 | 0.277 | 0.373 | 1.04 | CR |
| Dustin Pedroia | 142 | 19 | 12 | 0.323 | 0.401 | -0.17 | 2B |
| Alex Cora | 86 | 9 | 13 | 0.316 | 0.349 | 0.24 | 2B-SS |
| Wily Mo Pena | 69 | 8 | 7 | 0.230 | 0.319 | -0.09 | LF |
| Eric Hinske | 64 | 9 | 5 | 0.164 | 0.266 | -0.07 | 1B-LF-RF |
| Doug Mirabelli | 49 | 2 | 4 | 0.196 | 0.245 | -0.55 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 72.7 | 4.83 | 11 | 0 | X | -0.91 |
| Curt Schilling | 71.0 | 3.68 | 11 | 0 | X | 1.02 |
| Tim Wakefield | 68.0 | 4.24 | 11 | 0 | X | 0.09 |
| Josh Beckett | 57.7 | 2.65 | 9 | 0 | X | 2.20 |
| Julian Tavarez | 48.3 | 5.40 | 9 | 0 | X | -1.25 |
| Hideki Okajima | 25.7 | 1.05 | 0 | 24 | X | 1.94 |
| Joel Pineiro | 22.0 | 4.91 | 0 | 19 | X | -0.32 |
| Jonathan Papelbon | 19.3 | 1.86 | 0 | 19 | X | 1.10 |
| Kyle Snyder | 18.7 | 1.93 | 0 | 17 | X | 1.03 |
| J.C. Romero | 18.7 | 3.37 | 0 | 22 | X | 0.40 |
| Brendan Donnelly | 17.0 | 3.71 | 0 | 23 | X | 0.23 |
| Javier Lopez | 11.7 | 3.09 | 0 | 16 | X | 0.33 |
| Mike Timlin | 8.7 | 6.23 | 0 | 9 | X | -0.39 |
| Kason Gabbard | 5.0 | 3.60 | 1 | 0 | X | 0.08 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.37 |
| Manny Delcarmen | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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