| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 202 | 32 | 37 | 0.319 | 0.436 | 2.43 | DH |
| Julio Lugo | 199 | 24 | 26 | 0.236 | 0.291 | 0.51 | SS |
| Kevin Youkilis | 196 | 33 | 25 | 0.347 | 0.429 | 1.42 | 1B-3B |
| Manny Ramirez | 196 | 24 | 28 | 0.250 | 0.332 | 0.79 | LF-DH |
| Mike Lowell | 181 | 22 | 37 | 0.333 | 0.387 | 1.88 | 3B |
| Coco Crisp | 167 | 24 | 13 | 0.240 | 0.299 | -0.10 | CF |
| J.D. Drew | 159 | 22 | 13 | 0.237 | 0.346 | -0.12 | RF |
| Jason Varitek | 146 | 19 | 19 | 0.274 | 0.377 | 0.51 | CR |
| Dustin Pedroia | 119 | 16 | 7 | 0.269 | 0.361 | -0.42 | 2B |
| Alex Cora | 78 | 9 | 12 | 0.333 | 0.372 | 0.35 | 2B-SS |
| Wily Mo Pena | 59 | 8 | 6 | 0.269 | 0.356 | 0.06 | LF |
| Eric Hinske | 57 | 9 | 5 | 0.188 | 0.298 | 0.11 | 1B-LF-RF |
| Doug Mirabelli | 41 | 2 | 4 | 0.205 | 0.244 | -0.35 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Curt Schilling | 64.0 | 3.94 | 10 | 0 | X | 0.45 |
| Daisuke Matsuzaka | 62.0 | 4.06 | 9 | 0 | X | 0.25 |
| Tim Wakefield | 57.3 | 3.14 | 9 | 0 | X | 1.47 |
| Josh Beckett | 50.7 | 2.66 | 8 | 0 | X | 1.86 |
| Julian Tavarez | 42.7 | 5.27 | 8 | 0 | X | -1.03 |
| Hideki Okajima | 22.7 | 0.79 | 0 | 21 | X | 1.82 |
| Joel Pineiro | 18.3 | 5.89 | 0 | 16 | X | -0.71 |
| Jonathan Papelbon | 16.3 | 1.65 | 0 | 16 | X | 0.98 |
| Kyle Snyder | 15.7 | 1.72 | 0 | 14 | X | 0.92 |
| J.C. Romero | 14.7 | 2.45 | 0 | 18 | X | 0.61 |
| Brendan Donnelly | 14.0 | 4.50 | 0 | 19 | X | -0.09 |
| Javier Lopez | 9.3 | 2.89 | 0 | 11 | X | 0.29 |
| Mike Timlin | 8.7 | 6.23 | 0 | 9 | X | -0.40 |
| Kason Gabbard | 5.0 | 3.60 | 1 | 0 | X | 0.07 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.38 |
| Manny Delcarmen | 1.0 | 0.00 | 0 | 1 | X | 0.10 |
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