| Name | PA | R | RBI | BA | OBP | WAA | POS |
|---|---|---|---|---|---|---|---|
| David Ortiz | 189 | 30 | 34 | 0.312 | 0.429 | 2.22 | DH |
| Julio Lugo | 184 | 22 | 25 | 0.250 | 0.304 | 0.55 | SS |
| Manny Ramirez | 183 | 22 | 25 | 0.245 | 0.333 | 0.58 | LF-DH |
| Kevin Youkilis | 182 | 30 | 23 | 0.340 | 0.429 | 1.23 | 1B-3B |
| Mike Lowell | 169 | 21 | 35 | 0.333 | 0.391 | 1.86 | 3B |
| Coco Crisp | 154 | 22 | 12 | 0.236 | 0.286 | -0.10 | CF |
| J.D. Drew | 150 | 22 | 13 | 0.254 | 0.367 | 0.10 | RF |
| Jason Varitek | 138 | 19 | 19 | 0.280 | 0.377 | 0.70 | CR |
| Dustin Pedroia | 111 | 16 | 7 | 0.260 | 0.360 | -0.23 | 2B |
| Alex Cora | 74 | 9 | 12 | 0.333 | 0.365 | 0.44 | 2B-SS |
| Eric Hinske | 57 | 9 | 5 | 0.188 | 0.298 | 0.11 | 1B-LF-RF |
| Wily Mo Pena | 55 | 8 | 6 | 0.250 | 0.345 | 0.16 | LF |
| Doug Mirabelli | 37 | 2 | 4 | 0.200 | 0.243 | -0.25 | CR |
| Name | IP | ERA | Gs | Gr | SO | WAA |
|---|---|---|---|---|---|---|
| Daisuke Matsuzaka | 62.0 | 4.06 | 9 | 0 | X | 0.21 |
| Curt Schilling | 58.0 | 3.57 | 9 | 0 | X | 0.87 |
| Tim Wakefield | 52.3 | 2.41 | 8 | 0 | X | 2.20 |
| Josh Beckett | 50.7 | 2.66 | 8 | 0 | X | 1.83 |
| Julian Tavarez | 37.0 | 5.59 | 7 | 0 | X | -1.19 |
| Hideki Okajima | 21.7 | 0.42 | 0 | 20 | X | 1.92 |
| Joel Pineiro | 16.3 | 6.06 | 0 | 14 | X | -0.71 |
| Kyle Snyder | 15.7 | 1.72 | 0 | 14 | X | 0.91 |
| Jonathan Papelbon | 15.3 | 1.76 | 0 | 15 | X | 0.88 |
| J.C. Romero | 13.7 | 2.63 | 0 | 17 | X | 0.50 |
| Brendan Donnelly | 13.0 | 4.15 | 0 | 18 | X | 0.02 |
| Mike Timlin | 8.7 | 6.23 | 0 | 9 | X | -0.41 |
| Javier Lopez | 8.0 | 3.38 | 0 | 10 | X | 0.16 |
| Kason Gabbard | 5.0 | 3.60 | 1 | 0 | X | 0.07 |
| Devern Hansack | 4.7 | 7.71 | 1 | 1 | X | -0.38 |
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